LncRNA SNHG16 promotes tumor growth of pancreatic cancer by targeting miR-218-5p
Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved..
Small Nucleolar RNA Host Gene (SNHG16) is a novel cancer-related long noncoding RNA (lncRNA) and functions as an oncogene in a variety of cancers. Nonetheless, the expression patterns, biological function, and potential mechanisms in SNHG16 in pancreatic cancer (PC) remain rarely known. An increase in expression of SNHG16 in PC samples against adjacent normal tissues was shown here. Increased SNHG16 was linked intimately to the tumor-node-metastasis (TNM) stage, distant metastasis, tumor differentiation, and poor overall survival. Loss-of-function experiments revealed that SNHG16 knockdown suppressed the proliferation, formation of colonies, ability to migrate and invade in vitro, along with a lowered growth of the tumor in a mouse model. Mechanistically, SNHG16 might serve as a sponge competitive endogenous RNA (ceRNA) for miR-218-5p, thereby playing a role in regulating the expression of high mobility group box 1 (HMGB1) expression, a known direct miR-218-5p target in PC cells. These results provide novel insight into PC tumorigenesis and suggest that SNHG16 could serve as a likely therapeutic intervention in PC.
| Errataetall: |
RetractionIn: Biomed Pharmacother. 2024 Feb;171:116188. - PMID 38296726 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
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| Enthalten in: |
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 114(2019) vom: 14. Juni, Seite 108862 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Songyang [VerfasserIn] |
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| Links: |
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| Themen: |
HMGB1 Protein |
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| Anmerkungen: |
Date Completed 29.08.2019 Date Revised 07.02.2024 published: Print-Electronic RetractionIn: Biomed Pharmacother. 2024 Feb;171:116188. - PMID 38296726 Citation Status MEDLINE |
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| doi: |
10.1016/j.biopha.2019.108862 |
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| PPN (Katalog-ID): |
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| 500 | |a RetractionIn: Biomed Pharmacother. 2024 Feb;171:116188. - PMID 38296726 | ||
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| 520 | |a Copyright © 2019 The Authors. Published by Elsevier Masson SAS.. All rights reserved. | ||
| 520 | |a Small Nucleolar RNA Host Gene (SNHG16) is a novel cancer-related long noncoding RNA (lncRNA) and functions as an oncogene in a variety of cancers. Nonetheless, the expression patterns, biological function, and potential mechanisms in SNHG16 in pancreatic cancer (PC) remain rarely known. An increase in expression of SNHG16 in PC samples against adjacent normal tissues was shown here. Increased SNHG16 was linked intimately to the tumor-node-metastasis (TNM) stage, distant metastasis, tumor differentiation, and poor overall survival. Loss-of-function experiments revealed that SNHG16 knockdown suppressed the proliferation, formation of colonies, ability to migrate and invade in vitro, along with a lowered growth of the tumor in a mouse model. Mechanistically, SNHG16 might serve as a sponge competitive endogenous RNA (ceRNA) for miR-218-5p, thereby playing a role in regulating the expression of high mobility group box 1 (HMGB1) expression, a known direct miR-218-5p target in PC cells. These results provide novel insight into PC tumorigenesis and suggest that SNHG16 could serve as a likely therapeutic intervention in PC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Retracted Publication | |
| 650 | 4 | |a Invasion | |
| 650 | 4 | |a Pancreatic cancer | |
| 650 | 4 | |a Proliferation | |
| 650 | 4 | |a SNHG16 | |
| 650 | 4 | |a lncRNA | |
| 650 | 4 | |a miR-218-5p | |
| 650 | 7 | |a HMGB1 Protein |2 NLM | |
| 650 | 7 | |a MIRN218 microRNA, human |2 NLM | |
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| 650 | 7 | |a SNHG16 lncRNA, human |2 NLM | |
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| 700 | 1 | |a Liu, Kai |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yahui |e verfasserin |4 aut | |
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