Feasibility of Postmortem Imaging Assessment of Brain : Liver Volume Ratios with Pathological Validation
The Author(s). Published by S. Karger AG, Basel..
INTRODUCTION: Organ volumes at postmortem magnetic resonance imaging (PMMR) should reflect autopsy organ weights, and thus brain:liver volume ratios on imaging could be a surrogate for weight volume ratios at autopsy to indicate fetal growth restriction (FGR). This study aims to determine whether imaging-based organ volume ratios can replace autopsy organ weight ratios. Materials and Meth ods: An unselected cohort of perinatal deaths underwent PMMR prior to autopsy. Semiautomated brain and liver volumes were compared to autopsy organ weights and ratios. Ratios were compared using Bland-Altman plots, and intra- and interobserver variability was assessed.
RESULTS: A total 49 fetuses (25 male, 51%) at 17-42 weeks gestation were -assessed. There was a reasonable correlation between autopsy-derived brain:liver weight ratios (AB:LwR) and imaging-derived brain:liver volume ratios (IB:LvR; r = 0.8). The mean difference between AB:LwR and IB:LvR was +0.7 (95% limits of agreement range -1.5 to +2.9). In a small subset where FGR was present, the optimal IB:LvR ≥5.5 gave 83.3% sensitivity and 86.0% specificity for diagnosis. There was acceptable agreement within readers (mean difference in IB:LvRs 0.77 ± 2.21) and between readers -0.36 ± 0.68.
CONCLUSION: IB:LvR provides a surrogate evaluation of AB:LwRs, and may be used as a marker of FGR where autopsy is declined.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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Enthalten in: |
Fetal diagnosis and therapy - 46(2019), 6 vom: 29., Seite 360-367 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Shelmerdine, Susan C [VerfasserIn] |
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Links: |
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Themen: |
Brain |
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Anmerkungen: |
Date Completed 27.04.2020 Date Revised 11.02.2021 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1159/000497158 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM295914769 |
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500 | |a Citation Status MEDLINE | ||
520 | |a The Author(s). Published by S. Karger AG, Basel. | ||
520 | |a INTRODUCTION: Organ volumes at postmortem magnetic resonance imaging (PMMR) should reflect autopsy organ weights, and thus brain:liver volume ratios on imaging could be a surrogate for weight volume ratios at autopsy to indicate fetal growth restriction (FGR). This study aims to determine whether imaging-based organ volume ratios can replace autopsy organ weight ratios. Materials and Meth ods: An unselected cohort of perinatal deaths underwent PMMR prior to autopsy. Semiautomated brain and liver volumes were compared to autopsy organ weights and ratios. Ratios were compared using Bland-Altman plots, and intra- and interobserver variability was assessed | ||
520 | |a RESULTS: A total 49 fetuses (25 male, 51%) at 17-42 weeks gestation were -assessed. There was a reasonable correlation between autopsy-derived brain:liver weight ratios (AB:LwR) and imaging-derived brain:liver volume ratios (IB:LvR; r = 0.8). The mean difference between AB:LwR and IB:LvR was +0.7 (95% limits of agreement range -1.5 to +2.9). In a small subset where FGR was present, the optimal IB:LvR ≥5.5 gave 83.3% sensitivity and 86.0% specificity for diagnosis. There was acceptable agreement within readers (mean difference in IB:LvRs 0.77 ± 2.21) and between readers -0.36 ± 0.68 | ||
520 | |a CONCLUSION: IB:LvR provides a surrogate evaluation of AB:LwRs, and may be used as a marker of FGR where autopsy is declined | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Validation Study | |
650 | 4 | |a Brain | |
650 | 4 | |a Fetal growth restriction | |
650 | 4 | |a Liver ratio | |
650 | 4 | |a Magnetic resonance imaging | |
650 | 4 | |a Organ volumes | |
650 | 4 | |a Postmortem | |
650 | 4 | |a Radiology | |
700 | 1 | |a Chung, Kimberly L |e verfasserin |4 aut | |
700 | 1 | |a Hutchinson, John C |e verfasserin |4 aut | |
700 | 1 | |a Elliott, Claire |e verfasserin |4 aut | |
700 | 1 | |a Sebire, Neil J |e verfasserin |4 aut | |
700 | 1 | |a Arthurs, Owen J |e verfasserin |4 aut | |
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