User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip
IMPACT STATEMENT: With the ultimate goal in tissue engineering of approaching in vivo functionality as closely as possible, organ-on-a-chip (OoC) systems provide unprecedented game-changing opportunities by enabling creation of perfused three-dimensional tissues. Most of the recently developed OoC systems, however, require complex handling steps. Hence, a large gap still exists between technology development and collection of valuable biological data in a standardized medium- or high-throughput manner. The system presented here bridges this gap by providing a user-friendly framework for the parallelized creation of multiple physiologically relevant tissues, which could be applicable in every laboratory without additional equipment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Tissue engineering. Part A - 25(2019), 9-10 vom: 16. Mai, Seite 786-798 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schneider, Oliver [VerfasserIn] |
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| Links: |
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| Themen: |
Centrifugal microfluidics |
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| Anmerkungen: |
Date Completed 30.12.2019 Date Revised 11.10.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1089/ten.TEA.2019.0002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM295901365 |
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| 520 | |a IMPACT STATEMENT: With the ultimate goal in tissue engineering of approaching in vivo functionality as closely as possible, organ-on-a-chip (OoC) systems provide unprecedented game-changing opportunities by enabling creation of perfused three-dimensional tissues. Most of the recently developed OoC systems, however, require complex handling steps. Hence, a large gap still exists between technology development and collection of valuable biological data in a standardized medium- or high-throughput manner. The system presented here bridges this gap by providing a user-friendly framework for the parallelized creation of multiple physiologically relevant tissues, which could be applicable in every laboratory without additional equipment | ||
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| 700 | 1 | |a Sailer, Carla |e verfasserin |4 aut | |
| 700 | 1 | |a Loskill, Peter |e verfasserin |4 aut | |
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