High delayed mortality after the first episode of Clostridium difficile infection
Copyright © 2019. Published by Elsevier Ltd..
Clostridium difficile infection (CDI) is characterized by a high delayed and unrelated mortality. Predicting delayed mortality in CDI patients could allow the implementation of interventions that could reduce these events. A prospective multicentric study was carried out to investigate prognostic factors associated with mortality. It was based on a cohort (July 2015 to February 2016) of 295 patients presenting with CDI. Logistic regression was used and the model was calibrated using the Hosmer-Lemeshow test. The mortality rate at 75 days in our series was 18%. Age (>65 years), comorbidity (defined by heart failure, diabetes mellitus with any organ lesion, renal failure, active neoplasia or immunosuppression) and fecal incontinence at clinical presentation were associated with delayed (75-day) mortality. When present, each of the aforementioned variables added one point to the score. Mortalities with 0, 1, 2 and 3 points were 0%, 9.4%, 18.5% and 38.2%, respectively. The area under the ROC curve was 0.743, and the Hosmer-Lemeshow goodness-of-fit test p value was 0.875. Therefore, the prediction of high delayed mortality in CDI patients by our scoring system could promote measures for increasing survival in suitable cases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Anaerobe - 57(2019) vom: 28. Juni, Seite 93-98 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cózar, Alberto [VerfasserIn] |
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| Links: |
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| Themen: |
Aged |
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| Anmerkungen: |
Date Completed 05.11.2019 Date Revised 05.11.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.anaerobe.2019.04.004 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM295806680 |
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| 245 | 1 | 0 | |a High delayed mortality after the first episode of Clostridium difficile infection |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019. Published by Elsevier Ltd. | ||
| 520 | |a Clostridium difficile infection (CDI) is characterized by a high delayed and unrelated mortality. Predicting delayed mortality in CDI patients could allow the implementation of interventions that could reduce these events. A prospective multicentric study was carried out to investigate prognostic factors associated with mortality. It was based on a cohort (July 2015 to February 2016) of 295 patients presenting with CDI. Logistic regression was used and the model was calibrated using the Hosmer-Lemeshow test. The mortality rate at 75 days in our series was 18%. Age (>65 years), comorbidity (defined by heart failure, diabetes mellitus with any organ lesion, renal failure, active neoplasia or immunosuppression) and fecal incontinence at clinical presentation were associated with delayed (75-day) mortality. When present, each of the aforementioned variables added one point to the score. Mortalities with 0, 1, 2 and 3 points were 0%, 9.4%, 18.5% and 38.2%, respectively. The area under the ROC curve was 0.743, and the Hosmer-Lemeshow goodness-of-fit test p value was 0.875. Therefore, the prediction of high delayed mortality in CDI patients by our scoring system could promote measures for increasing survival in suitable cases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Clostridium difficile | |
| 650 | 4 | |a Comorbidity | |
| 650 | 4 | |a Fecal incontinence | |
| 650 | 4 | |a Immunosuppression | |
| 650 | 4 | |a Mortality | |
| 700 | 1 | |a Ramos-Martínez, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Merino, Esperanza |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-García, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Shaw, Evelyn |e verfasserin |4 aut | |
| 700 | 1 | |a Marrodán, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Calbo, Esther |e verfasserin |4 aut | |
| 700 | 1 | |a Bereciartúa, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Muñoz, Luis A |e verfasserin |4 aut | |
| 700 | 1 | |a Salavert, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Rodríguez, M Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a García, Dácil |e verfasserin |4 aut | |
| 700 | 1 | |a Bravo-Ferrer, J María |e verfasserin |4 aut | |
| 700 | 1 | |a Gálvez-Acebal, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Henríquez, César |e verfasserin |4 aut | |
| 700 | 1 | |a Cuquet, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Gil-Campesino, Helena |e verfasserin |4 aut | |
| 700 | 1 | |a Torres, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Porto, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Royuela, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Cobo, Javier |e verfasserin |4 aut | |
| 700 | 0 | |a Study group |e verfasserin |4 aut | |
| 700 | 1 | |a Romero, José |e investigator |4 oth | |
| 700 | 1 | |a Muriel, Alfonso |e investigator |4 oth | |
| 700 | 1 | |a Giner, Livia |e investigator |4 oth | |
| 700 | 1 | |a Federico, Ferrere |e investigator |4 oth | |
| 700 | 1 | |a Rocío, Martínez-Ruiz S |e investigator |4 oth | |
| 700 | 1 | |a Martos, Purificación |e investigator |4 oth | |
| 700 | 1 | |a Sardiña, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Elena, Aguirre |e investigator |4 oth | |
| 700 | 1 | |a Badía, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Perales, Alfonso |e investigator |4 oth | |
| 700 | 1 | |a De Santos-Castro, Pedro A |e investigator |4 oth | |
| 700 | 1 | |a Miguel, AngelBratos-Pérez |e investigator |4 oth | |
| 700 | 1 | |a Cuellar, Sandra |e investigator |4 oth | |
| 700 | 1 | |a Eva, Gonzalez |e investigator |4 oth | |
| 700 | 1 | |a Llinares, Pedro |e investigator |4 oth | |
| 700 | 1 | |a Laura, Castelo |e investigator |4 oth | |
| 700 | 1 | |a Morales, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Delgado-Iribarren, Alberto |e investigator |4 oth | |
| 700 | 1 | |a Mairal, Pilar |e investigator |4 oth | |
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