The importance of microRNAs in the development of systemic autoimmune disorders
MicroRNAs (miRNAs) are 18-25 nucleotide long, single stranded, endogenous, non-coding small RNAs playing an important role in regulating gene expression at posttranscriptional level. miRNAs control approximately 90% of protein-coding genes, and play a central role in various biological processes including immune cell lineage commitment, differentiation, proliferation, apoptosis and maintenance of immune homeostasis. Changes in the expression of certain miRNAs may lead to the development of many diseases, including systemic autoimmune diseases. In this study, we summarize the biogenesis of miRNAs, their role in regulation of the immune system, and review the latest research findings in systemic lupus erythematosus, primary Sjögren's syndrome, rheumatoid arthritis and systemic sclerosis. In the future, miRNAs may help not only in establishing diagnosis and prognosis but potentially serve as targets for modern therapeutic approaches in autoimmune diseases. Orv Hetil. 2019; 160(15): 563-572.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:160 |
|---|---|
| Enthalten in: |
Orvosi hetilap - 160(2019), 15 vom: 19. Apr., Seite 563-572 |
| Sprache: |
Ungarisch |
|---|
| Weiterer Titel: |
A mikro-RNS-ek jelentősége szisztémás autoimmun betegségek kialakulásában |
|---|
| Beteiligte Personen: |
Jámbor, Ilona [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 05.11.2019 Date Revised 05.11.2019 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1556/650.2019.31349 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM29579089X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM29579089X | ||
| 003 | DE-627 | ||
| 005 | 20231225084426.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||hun c | ||
| 024 | 7 | |a 10.1556/650.2019.31349 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0985.xml |
| 035 | |a (DE-627)NLM29579089X | ||
| 035 | |a (NLM)30957538 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a hun | ||
| 100 | 1 | |a Jámbor, Ilona |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The importance of microRNAs in the development of systemic autoimmune disorders |
| 246 | 3 | 3 | |a A mikro-RNS-ek jelentősége szisztémás autoimmun betegségek kialakulásában |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.11.2019 | ||
| 500 | |a Date Revised 05.11.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a MicroRNAs (miRNAs) are 18-25 nucleotide long, single stranded, endogenous, non-coding small RNAs playing an important role in regulating gene expression at posttranscriptional level. miRNAs control approximately 90% of protein-coding genes, and play a central role in various biological processes including immune cell lineage commitment, differentiation, proliferation, apoptosis and maintenance of immune homeostasis. Changes in the expression of certain miRNAs may lead to the development of many diseases, including systemic autoimmune diseases. In this study, we summarize the biogenesis of miRNAs, their role in regulation of the immune system, and review the latest research findings in systemic lupus erythematosus, primary Sjögren's syndrome, rheumatoid arthritis and systemic sclerosis. In the future, miRNAs may help not only in establishing diagnosis and prognosis but potentially serve as targets for modern therapeutic approaches in autoimmune diseases. Orv Hetil. 2019; 160(15): 563-572 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a microRNA | |
| 650 | 4 | |a mikro-RNS | |
| 650 | 4 | |a primary Sjögren’s syndrome | |
| 650 | 4 | |a primer Sjögren-szindróma | |
| 650 | 4 | |a rheumatoid arthritis | |
| 650 | 4 | |a systemic lupus erythematosus | |
| 650 | 4 | |a systemic sclerosis | |
| 650 | 4 | |a szisztémás lupus erythematosus | |
| 650 | 4 | |a szisztémás sclerosis | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 700 | 1 | |a Szabó, Krisztina |e verfasserin |4 aut | |
| 700 | 1 | |a Zeher, Margit |e verfasserin |4 aut | |
| 700 | 1 | |a Papp, Gábor |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Orvosi hetilap |d 1949 |g 160(2019), 15 vom: 19. Apr., Seite 563-572 |w (DE-627)NLM000021601 |x 1788-6120 |7 nnns |
| 773 | 1 | 8 | |g volume:160 |g year:2019 |g number:15 |g day:19 |g month:04 |g pages:563-572 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1556/650.2019.31349 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 160 |j 2019 |e 15 |b 19 |c 04 |h 563-572 | ||