Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype : Insights from an analysis of 500 cases
Copyright © 2019 Elsevier Inc. All rights reserved..
BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry.
METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed.
RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001).
CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects.
| Errataetall: |
CommentIn: Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):11-13. - PMID 33506886 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
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| Enthalten in: |
Clinical immunology (Orlando, Fla.) - 203(2019) vom: 20. Juni, Seite 1-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Watad, Abdulla [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.04.2020 Date Revised 29.01.2021 published: Print-Electronic CommentIn: Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):11-13. - PMID 33506886 Citation Status MEDLINE |
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| doi: |
10.1016/j.clim.2019.03.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM295450967 |
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| 100 | 1 | |a Watad, Abdulla |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype |b Insights from an analysis of 500 cases |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Eur Rev Med Pharmacol Sci. 2021 Jan;25(1):11-13. - PMID 33506886 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: We investigated the pattern of reported immune diseases in the international ASIA syndrome registry | ||
| 520 | |a METHODS: Data from 500 subjects exposed to adjuvants from the ASIA syndrome international registry were analysed | ||
| 520 | |a RESULTS: The patient mean age was 43 ± 17 years and 89% were female. Within the reported immune diseases, 69% were well-defined immune diseases (autoimmune, autoinflammation, and mixed pattern diseases). Among the well-defined immune diseases following the exposure to adjuvants, polygenic autoimmune diseases were significantly higher than autoinflammatory disorders (92.7% vs 5.8%, respectively, p < 0.001). Polygenic autoimmune diseases such as connective tissue diseases were significantly linked to the exposure to HBV vaccine (OR 3.15 [95%CI 1.08-9.23], p = 0.036). Polygenic autoinflammatory diseases were significantly associated with the exposure to influenza vaccination (OR 10.98 [95%CI 3.81-31.67], p < 0.0001) | ||
| 520 | |a CONCLUSIONS: Immune conditions following vaccination are rare, and among these, polygenic autoimmune diseases represent the vast majority of the well-defined immune diseases reported under the umbrella ASIA syndrome. However, vaccines benefit outweighs their autoimmune side effects | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a ASIA syndrome | |
| 650 | 4 | |a Foreign material | |
| 650 | 4 | |a International syndrome registry | |
| 650 | 4 | |a Silicone breast implants | |
| 650 | 4 | |a Vaccines | |
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| 650 | 7 | |a Hepatitis B Vaccines |2 NLM | |
| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Bragazzi, Nicola Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a McGonagle, Dennis |e verfasserin |4 aut | |
| 700 | 1 | |a Adawi, Mohammed |e verfasserin |4 aut | |
| 700 | 1 | |a Bridgewood, Charlie |e verfasserin |4 aut | |
| 700 | 1 | |a Damiani, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Alijotas-Reig, Jaume |e verfasserin |4 aut | |
| 700 | 1 | |a Esteve-Valverde, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Quaresma, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Amital, Howard |e verfasserin |4 aut | |
| 700 | 1 | |a Shoenfeld, Yehuda |e verfasserin |4 aut | |
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