Assessment of liver T1 mapping in fontan patients and its correlation with magnetic resonance elastography-derived liver stiffness
OBJECTIVES: To explore the utility of liver T1 mapping in Fontan patients and its correlation to magnetic resonance elastography (MRE)-derived liver stiffness.
BACKGROUND AND AIMS: Liver disease is a major long-term extra cardiac complication in the Fontan population. MRE is frequently used to quantify liver stiffness in Fontan patients; however, it has certain limitations. Native T1 mapping by cardiac magnetic resonance (CMR) is useful in assessment of cardiac fibrosis, but its potential in evaluating liver fibrosis and its correlation to MRE-derived liver stiffness in Fontan patients have not been reported.
METHODS: Fontan patients who underwent CMR and MRE were included. Liver Native T1, extracellular volume (ECV) and delta coefficients were measured and correlated with MRE-derived liver stiffness in all Fontan patients. Native liver T1 in Fontan patients were compared to normal controls with biventricular circulation and no known liver disease.
RESULTS: A total of 17 Fontan patients and 7 normal controls were included in this study. Fontan patients had significantly higher liver native T1 (690 ± 41 ms vs 620 ± 35 ms; p < 0.001) as compared to controls. There was strong positive correlation between MRE derived liver stiffness and liver native T1 (r = 0.81, p < 0.001).
CONCLUSIONS: Liver native T1 was significantly elevated in Fontan patients compared to controls and strongly correlated with MRE-derived liver stiffness. This technique may prove to be a useful noninvasive imaging biomarker for assessing liver fibrosis in the Fontan population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Abdominal radiology (New York) - 44(2019), 7 vom: 01. Juli, Seite 2403-2408 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ramachandran, Preeti [VerfasserIn] |
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| Links: |
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| Themen: |
Congenital heart disease |
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| Anmerkungen: |
Date Completed 09.09.2020 Date Revised 09.09.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/s00261-019-01990-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM295257490 |
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| 100 | 1 | |a Ramachandran, Preeti |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Assessment of liver T1 mapping in fontan patients and its correlation with magnetic resonance elastography-derived liver stiffness |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 09.09.2020 | ||
| 500 | |a Date Revised 09.09.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To explore the utility of liver T1 mapping in Fontan patients and its correlation to magnetic resonance elastography (MRE)-derived liver stiffness | ||
| 520 | |a BACKGROUND AND AIMS: Liver disease is a major long-term extra cardiac complication in the Fontan population. MRE is frequently used to quantify liver stiffness in Fontan patients; however, it has certain limitations. Native T1 mapping by cardiac magnetic resonance (CMR) is useful in assessment of cardiac fibrosis, but its potential in evaluating liver fibrosis and its correlation to MRE-derived liver stiffness in Fontan patients have not been reported | ||
| 520 | |a METHODS: Fontan patients who underwent CMR and MRE were included. Liver Native T1, extracellular volume (ECV) and delta coefficients were measured and correlated with MRE-derived liver stiffness in all Fontan patients. Native liver T1 in Fontan patients were compared to normal controls with biventricular circulation and no known liver disease | ||
| 520 | |a RESULTS: A total of 17 Fontan patients and 7 normal controls were included in this study. Fontan patients had significantly higher liver native T1 (690 ± 41 ms vs 620 ± 35 ms; p < 0.001) as compared to controls. There was strong positive correlation between MRE derived liver stiffness and liver native T1 (r = 0.81, p < 0.001) | ||
| 520 | |a CONCLUSIONS: Liver native T1 was significantly elevated in Fontan patients compared to controls and strongly correlated with MRE-derived liver stiffness. This technique may prove to be a useful noninvasive imaging biomarker for assessing liver fibrosis in the Fontan population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Congenital heart disease | |
| 650 | 4 | |a Fontan | |
| 650 | 4 | |a Liver fibrosis | |
| 650 | 4 | |a Parametric mapping | |
| 650 | 4 | |a Single ventricle | |
| 700 | 1 | |a Serai, Suraj D |e verfasserin |4 aut | |
| 700 | 1 | |a Veldtman, Gruschen R |e verfasserin |4 aut | |
| 700 | 1 | |a Lang, Sean M |e verfasserin |4 aut | |
| 700 | 1 | |a Mazur, Wojciech |e verfasserin |4 aut | |
| 700 | 1 | |a Trout, Andrew T |e verfasserin |4 aut | |
| 700 | 1 | |a Dillman, Jonathan R |e verfasserin |4 aut | |
| 700 | 1 | |a Fleck, Robert J |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Michael D |e verfasserin |4 aut | |
| 700 | 1 | |a Alsaied, Tarek |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Ryan A |e verfasserin |4 aut | |
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