Tunable drug release from blend poly(vinyl pyrrolidone)-ethyl cellulose nanofibers
Copyright © 2019 Elsevier B.V. All rights reserved..
The management of pain and inflammation arising from wounds is essential in obtaining effective healing rates. The application of a wound dressing loaded with an anti-inflammatory drug would enable both issues to be ameliorated, and the aim of this work was to fabricate such a dressing by electrospinning. Fibers comprising ethyl cellulose (EC) and poly(vinyl pyrrolidone) (PVP) loaded with naproxen (Nap) were developed to be used in the early stages of wound care. A family of PVP/EC/Nap systems was prepared by varying the PVP: EC ratio. In all cases, the products of electrospinning comprise non-woven mats of fibers which generally have smooth and cylindrical morphologies. The formulations exist as amorphous solid dispersions, and there appear to be intermolecular interactions between the three components. Adjusting the polymer ratios results in tunable drug release, and formulations have been produced which give zero-order drug release over 20 and 80 h. The fiber mats generated in this work thus have great potential to be used as dressings for the treatment of wound pain and inflammation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:562 |
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| Enthalten in: |
International journal of pharmaceutics - 562(2019) vom: 01. Mai, Seite 172-179 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Godakanda, V Umayangana [VerfasserIn] |
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| Links: |
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| Themen: |
57Y76R9ATQ |
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| Anmerkungen: |
Date Completed 05.08.2019 Date Revised 05.08.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijpharm.2019.03.035 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM295212519 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
| 520 | |a The management of pain and inflammation arising from wounds is essential in obtaining effective healing rates. The application of a wound dressing loaded with an anti-inflammatory drug would enable both issues to be ameliorated, and the aim of this work was to fabricate such a dressing by electrospinning. Fibers comprising ethyl cellulose (EC) and poly(vinyl pyrrolidone) (PVP) loaded with naproxen (Nap) were developed to be used in the early stages of wound care. A family of PVP/EC/Nap systems was prepared by varying the PVP: EC ratio. In all cases, the products of electrospinning comprise non-woven mats of fibers which generally have smooth and cylindrical morphologies. The formulations exist as amorphous solid dispersions, and there appear to be intermolecular interactions between the three components. Adjusting the polymer ratios results in tunable drug release, and formulations have been produced which give zero-order drug release over 20 and 80 h. The fiber mats generated in this work thus have great potential to be used as dressings for the treatment of wound pain and inflammation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Electrospinning | |
| 650 | 4 | |a Ethyl cellulose | |
| 650 | 4 | |a Naproxen | |
| 650 | 4 | |a Poly(vinyl pyrrolidone) | |
| 650 | 4 | |a Wound dressing | |
| 650 | 7 | |a Anti-Inflammatory Agents, Non-Steroidal |2 NLM | |
| 650 | 7 | |a Naproxen |2 NLM | |
| 650 | 7 | |a 57Y76R9ATQ |2 NLM | |
| 650 | 7 | |a ethyl cellulose |2 NLM | |
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| 650 | 7 | |a Cellulose |2 NLM | |
| 650 | 7 | |a 9004-34-6 |2 NLM | |
| 650 | 7 | |a Povidone |2 NLM | |
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| 700 | 1 | |a Li, Heyu |e verfasserin |4 aut | |
| 700 | 1 | |a Alquezar, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Lixiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Li-Min |e verfasserin |4 aut | |
| 700 | 1 | |a de Silva, Rohini |e verfasserin |4 aut | |
| 700 | 1 | |a de Silva, K M Nalin |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, Gareth R |e verfasserin |4 aut | |
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