Health-related quality of life in glomerular disease
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved..
There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:95 |
|---|---|
| Enthalten in: |
Kidney international - 95(2019), 5 vom: 01. Mai, Seite 1209-1224 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Canetta, Pietro A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Edema |
|---|
| Anmerkungen: |
Date Completed 02.04.2020 Date Revised 18.11.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.kint.2018.12.018 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM295209593 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM295209593 | ||
| 003 | DE-627 | ||
| 005 | 20231225083147.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.kint.2018.12.018 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0984.xml |
| 035 | |a (DE-627)NLM295209593 | ||
| 035 | |a (NLM)30898342 | ||
| 035 | |a (PII)S0085-2538(19)30046-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Canetta, Pietro A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Health-related quality of life in glomerular disease |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 02.04.2020 | ||
| 500 | |a Date Revised 18.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a There is scant literature describing the effect of glomerular disease on health-related quality of life (HRQOL). The Cure Glomerulonephropathy study (CureGN) is an international longitudinal cohort study of children and adults with four primary glomerular diseases (minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and IgA nephropathy). HRQOL is systematically assessed using items from the Patient-Reported Outcomes Measurement Informative System (PROMIS). We assessed the relationship between HRQOL and demographic and clinical variables in 478 children and 1115 adults at the time of enrollment into CureGN. Domains measured by PROMIS items included global assessments of health, mobility, anxiety, fatigue, and sleep impairment, as well as a derived composite measure incorporating all measured domains. Multivariable models were created that explained 7 to 32% of variance in HRQOL. Patient-reported edema consistently had the strongest and most robust association with each measured domain of HRQOL in multivariable analysis (adjusted β [95% CI] for composite PROMIS score in children, -5.2 [-7.1 to -3.4]; for composite PROMIS score in adults, -6.1 [-7.4 to -4.9]). Female sex, weight (particularly obesity), and estimated glomerular filtration rate were also associated with some, but not all, domains of HRQOL. Primary diagnosis, disease duration, and exposure to immunosuppression were not associated with HRQOL after adjustment. Sensitivity analyses and interaction testing demonstrated no significant association between disease duration or immunosuppression and any measured domain of HRQOL. Thus, patient-reported edema has a consistent negative association with HRQOL in patients with primary glomerular diseases, with substantially greater impact than other demographic and clinical variables | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a edema | |
| 650 | 4 | |a health-related quality of life | |
| 650 | 4 | |a patient-reported outcomes | |
| 650 | 4 | |a primary glomerular disease | |
| 700 | 1 | |a Troost, Jonathan P |e verfasserin |4 aut | |
| 700 | 1 | |a Mahoney, Shannon |e verfasserin |4 aut | |
| 700 | 1 | |a Kogon, Amy J |e verfasserin |4 aut | |
| 700 | 1 | |a Carlozzi, Noelle |e verfasserin |4 aut | |
| 700 | 1 | |a Bartosh, Sharon M |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Davis, T Keefe |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, Hilda |e verfasserin |4 aut | |
| 700 | 1 | |a Fornoni, Alessia |e verfasserin |4 aut | |
| 700 | 1 | |a Gbadegesin, Rasheed A |e verfasserin |4 aut | |
| 700 | 1 | |a Herreshoff, Emily |e verfasserin |4 aut | |
| 700 | 1 | |a Mahan, John D |e verfasserin |4 aut | |
| 700 | 1 | |a Nachman, Patrick H |e verfasserin |4 aut | |
| 700 | 1 | |a Selewski, David T |e verfasserin |4 aut | |
| 700 | 1 | |a Sethna, Christine B |e verfasserin |4 aut | |
| 700 | 1 | |a Srivastava, Tarak |e verfasserin |4 aut | |
| 700 | 1 | |a Tuttle, Katherine R |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Chia-Shi |e verfasserin |4 aut | |
| 700 | 1 | |a Falk, Ronald J |e verfasserin |4 aut | |
| 700 | 1 | |a Gharavi, Ali G |e verfasserin |4 aut | |
| 700 | 1 | |a Gillespie, Brenda W |e verfasserin |4 aut | |
| 700 | 1 | |a Greenbaum, Larry A |e verfasserin |4 aut | |
| 700 | 1 | |a Holzman, Lawrence B |e verfasserin |4 aut | |
| 700 | 1 | |a Kretzler, Matthias |e verfasserin |4 aut | |
| 700 | 1 | |a Robinson, Bruce M |e verfasserin |4 aut | |
| 700 | 1 | |a Smoyer, William E |e verfasserin |4 aut | |
| 700 | 1 | |a Guay-Woodford, Lisa M |e verfasserin |4 aut | |
| 700 | 1 | |a Reeve, Bryce |e verfasserin |4 aut | |
| 700 | 1 | |a Gipson, Debbie S |e verfasserin |4 aut | |
| 700 | 0 | |a CureGN Consortium |e verfasserin |4 aut | |
| 700 | 1 | |a Ahn, Wooin |e investigator |4 oth | |
| 700 | 1 | |a Appel, Gerald B |e investigator |4 oth | |
| 700 | 1 | |a Babayev, Revekka |e investigator |4 oth | |
| 700 | 1 | |a Batal, Ibrahim |e investigator |4 oth | |
| 700 | 1 | |a Bomback, Andrew S |e investigator |4 oth | |
| 700 | 1 | |a Brown, Eric |e investigator |4 oth | |
| 700 | 1 | |a Campenot, Eric S |e investigator |4 oth | |
| 700 | 1 | |a Canetta, Pietro |e investigator |4 oth | |
| 700 | 1 | |a Carlassara, Lucrezia |e investigator |4 oth | |
| 700 | 1 | |a Chan, Brenda |e investigator |4 oth | |
| 700 | 1 | |a Chatterjee, Debanjana |e investigator |4 oth | |
| 700 | 1 | |a D'Agati, Vivette D |e investigator |4 oth | |
| 700 | 1 | |a Delbarba, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Dogra, Samriti |e investigator |4 oth | |
| 700 | 1 | |a Fernandez, Hilda |e investigator |4 oth | |
| 700 | 1 | |a Foroncewicz, Bartosz |e investigator |4 oth | |
| 700 | 1 | |a Gharavi, Ali G |e investigator |4 oth | |
| 700 | 1 | |a Ghiggeri, Gian Marco |e investigator |4 oth | |
| 700 | 1 | |a Hines, William H |e investigator |4 oth | |
| 700 | 1 | |a Husain, S Ali |e investigator |4 oth | |
| 700 | 1 | |a Jain, Namrata G |e investigator |4 oth | |
| 700 | 1 | |a Khairallah, Pascale |e investigator |4 oth | |
| 700 | 1 | |a Kil, Byum Hee |e investigator |4 oth | |
| 700 | 1 | |a Kiryluk, Krzysztof |e investigator |4 oth | |
| 700 | 1 | |a Jeyabalan, Anushya |e investigator |4 oth | |
| 700 | 1 | |a Lau, Wai L |e investigator |4 oth | |
| 700 | 1 | |a Lin, Fangming |e investigator |4 oth | |
| 700 | 1 | |a Lugani, Francesca |e investigator |4 oth | |
| 700 | 1 | |a Marasa, Maddalena |e investigator |4 oth | |
| 700 | 1 | |a Markowitz, Glen |e investigator |4 oth | |
| 700 | 1 | |a Mohan, Sumit |e investigator |4 oth | |
| 700 | 1 | |a Mu, Xueru |e investigator |4 oth | |
| 700 | 1 | |a Mucha, Krzysztof |e investigator |4 oth | |
| 700 | 1 | |a Nickolas, Thomas L |e investigator |4 oth | |
| 700 | 1 | |a Piva, Stacy |e investigator |4 oth | |
| 700 | 1 | |a Radhakrishnan, Jai |e investigator |4 oth | |
| 700 | 1 | |a Rao, Maya K |e investigator |4 oth | |
| 700 | 1 | |a Renu, Regunathan-Shenk |e investigator |4 oth | |
| 700 | 1 | |a Sanna-Cherchi, Simone |e investigator |4 oth | |
| 700 | 1 | |a Santoriello, Dominick |e investigator |4 oth | |
| 700 | 1 | |a Shirazian, Shayan |e investigator |4 oth | |
| 700 | 1 | |a Stokes, Michael B |e investigator |4 oth | |
| 700 | 1 | |a Uy, Natalie |e investigator |4 oth | |
| 700 | 1 | |a Valeri, Anthony M |e investigator |4 oth | |
| 700 | 1 | |a Greenbaum, Larry A |e investigator |4 oth | |
| 700 | 1 | |a Smoyer, William E |e investigator |4 oth | |
| 700 | 1 | |a Al-Uzri, Amira |e investigator |4 oth | |
| 700 | 1 | |a Ambruzs, Josephine |e investigator |4 oth | |
| 700 | 1 | |a Ashoor, Isa |e investigator |4 oth | |
| 700 | 1 | |a Aviles, Diego |e investigator |4 oth | |
| 700 | 1 | |a Baracco, Rossana |e investigator |4 oth | |
| 700 | 1 | |a Barcia, John |e investigator |4 oth | |
| 700 | 1 | |a Bartosh, Sharon |e investigator |4 oth | |
| 700 | 1 | |a Belsha, Craig |e investigator |4 oth | |
| 700 | 1 | |a Bowers, Corinna |e investigator |4 oth | |
| 700 | 1 | |a Braun, Michael C |e investigator |4 oth | |
| 700 | 1 | |a Cai, Yi |e investigator |4 oth | |
| 700 | 1 | |a Chernitskiy, Vladimir |e investigator |4 oth | |
| 700 | 1 | |a Chishti, Aftab |e investigator |4 oth | |
| 700 | 1 | |a Claes, Donna |e investigator |4 oth | |
| 700 | 1 | |a Clark, Kira |e investigator |4 oth | |
| 700 | 1 | |a Cramer, Carl |e investigator |4 oth | |
| 700 | 1 | |a Davis, Keefe |e investigator |4 oth | |
| 700 | 1 | |a Erkan, Elif |e investigator |4 oth | |
| 700 | 1 | |a Feig, Daniel |e investigator |4 oth | |
| 700 | 1 | |a Freundlich, Michael |e investigator |4 oth | |
| 700 | 1 | |a Gaut, Joseph |e investigator |4 oth | |
| 700 | 1 | |a Gbadegesin, Rasheed |e investigator |4 oth | |
| 700 | 1 | |a Hanna, Melisha |e investigator |4 oth | |
| 700 | 1 | |a Hidalgo, Guillermo |e investigator |4 oth | |
| 700 | 1 | |a Hooper, David |e investigator |4 oth | |
| 700 | 1 | |a Hunley, Tracy E |e investigator |4 oth | |
| 700 | 1 | |a Jain, Amrish |e investigator |4 oth | |
| 700 | 1 | |a Kallash, Mahmoud |e investigator |4 oth | |
| 700 | 1 | |a Kamel, Margo |e investigator |4 oth | |
| 700 | 1 | |a Khalid, Myda |e investigator |4 oth | |
| 700 | 1 | |a Klein, Jon B |e investigator |4 oth | |
| 700 | 1 | |a Kump, Theresa |e investigator |4 oth | |
| 700 | 1 | |a Lane, Jerome C |e investigator |4 oth | |
| 700 | 1 | |a Liapis, Helen |e investigator |4 oth | |
| 700 | 1 | |a Mahan, John |e investigator |4 oth | |
| 700 | 1 | |a Nester, Carla |e investigator |4 oth | |
| 700 | 1 | |a Pan, Cynthia |e investigator |4 oth | |
| 700 | 1 | |a Patterson, Larry |e investigator |4 oth | |
| 700 | 1 | |a Patel, Hiren |e investigator |4 oth | |
| 700 | 1 | |a Raad, Alice |e investigator |4 oth | |
| 700 | 1 | |a Revell, Adelaide |e investigator |4 oth | |
| 700 | 1 | |a Rheault, Michelle N |e investigator |4 oth | |
| 700 | 1 | |a Silva, Cynthia |e investigator |4 oth | |
| 700 | 1 | |a Sreedharan, Rajasree |e investigator |4 oth | |
| 700 | 1 | |a Srivastava, Tarak |e investigator |4 oth | |
| 700 | 1 | |a Steinke, Julia |e investigator |4 oth | |
| 700 | 1 | |a Sumner, Susan |e investigator |4 oth | |
| 700 | 1 | |a Twombley, Katherine |e investigator |4 oth | |
| 700 | 1 | |a Wenderfer, Scott E |e investigator |4 oth | |
| 700 | 1 | |a Vasylyeva, Tetyana L |e investigator |4 oth | |
| 700 | 1 | |a Wang, Chia-Shi |e investigator |4 oth | |
| 700 | 1 | |a Weaver, Donald J |e investigator |4 oth | |
| 700 | 1 | |a Wong, Craig S |e investigator |4 oth | |
| 700 | 1 | |a Yin, Hong |e investigator |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Kidney international |d 1972 |g 95(2019), 5 vom: 01. Mai, Seite 1209-1224 |w (DE-627)NLM000007188 |x 1523-1755 |7 nnns |
| 773 | 1 | 8 | |g volume:95 |g year:2019 |g number:5 |g day:01 |g month:05 |g pages:1209-1224 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.kint.2018.12.018 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 95 |j 2019 |e 5 |b 01 |c 05 |h 1209-1224 | ||