Prevalence and correlates of Benign Pancreatic Hyperenzymemia in a large general population sample : The Damocles sword perception
Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved..
BACKGROUND: Benign Pancreatic Hyperenzymemia (BPH) is characterized by a long-term increase of serum pancreatic enzymes (PE) in otherwise healthy subjects. The study investigates the prevalence and correlates of the condition using data from Electronic Health Records (EHR) in a large sample of general population, to identify subjects potentially affected by BPH.
METHODS: Cross-sectional retrospective observational study integrated by a follow-up visit.
RESULTS: The database of a reference laboratory identified, out of 577.251 admittances from 2011 to 2015, 4964 patients tested at least for one PE assay and 1688 subjects who had at least 3 PE tests (normal or increased) over two years. Forty-two individuals showed an increase of PE at least three times throughout 2 years without any evidence of pancreatic disease, even after matching with the ICD 9-CM code in the GPs database. Data retrieved at follow-up visit showed that for 34 the diagnosis of BPH could be made.
CONCLUSIONS: Our data indicate that BPH prevalence among subjects underwent blood testing for multiple PE testing is 2%. This condition, even if not a disease, is perceived by nearly all the BPH patients as a serious threat to their life. Further studies are needed to manage its heavy psychological impact.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2019 |
---|---|
Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
---|---|
Enthalten in: |
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al. - 19(2019), 3 vom: 01. Apr., Seite 409-413 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Cavallo, Pierpaolo [VerfasserIn] |
---|
Links: |
---|
Themen: |
Benign hyperenzymemia |
---|
Anmerkungen: |
Date Completed 03.12.2019 Date Revised 03.12.2019 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.pan.2019.03.003 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM295131306 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM295131306 | ||
003 | DE-627 | ||
005 | 20231225083004.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2019 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.pan.2019.03.003 |2 doi | |
028 | 5 | 2 | |a pubmed24n0983.xml |
035 | |a (DE-627)NLM295131306 | ||
035 | |a (NLM)30890309 | ||
035 | |a (PII)S1424-3903(19)30065-1 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Cavallo, Pierpaolo |e verfasserin |4 aut | |
245 | 1 | 0 | |a Prevalence and correlates of Benign Pancreatic Hyperenzymemia in a large general population sample |b The Damocles sword perception |
264 | 1 | |c 2019 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 03.12.2019 | ||
500 | |a Date Revised 03.12.2019 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved. | ||
520 | |a BACKGROUND: Benign Pancreatic Hyperenzymemia (BPH) is characterized by a long-term increase of serum pancreatic enzymes (PE) in otherwise healthy subjects. The study investigates the prevalence and correlates of the condition using data from Electronic Health Records (EHR) in a large sample of general population, to identify subjects potentially affected by BPH | ||
520 | |a METHODS: Cross-sectional retrospective observational study integrated by a follow-up visit | ||
520 | |a RESULTS: The database of a reference laboratory identified, out of 577.251 admittances from 2011 to 2015, 4964 patients tested at least for one PE assay and 1688 subjects who had at least 3 PE tests (normal or increased) over two years. Forty-two individuals showed an increase of PE at least three times throughout 2 years without any evidence of pancreatic disease, even after matching with the ICD 9-CM code in the GPs database. Data retrieved at follow-up visit showed that for 34 the diagnosis of BPH could be made | ||
520 | |a CONCLUSIONS: Our data indicate that BPH prevalence among subjects underwent blood testing for multiple PE testing is 2%. This condition, even if not a disease, is perceived by nearly all the BPH patients as a serious threat to their life. Further studies are needed to manage its heavy psychological impact | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Observational Study | |
650 | 4 | |a Benign hyperenzymemia | |
650 | 4 | |a Electronic health records | |
650 | 4 | |a Epidemiology | |
650 | 4 | |a General population | |
650 | 4 | |a General practitioner | |
650 | 4 | |a Pancreatic enzyme | |
700 | 1 | |a Carpinelli, Luna |e verfasserin |4 aut | |
700 | 1 | |a Zingone, Fabiana |e verfasserin |4 aut | |
700 | 1 | |a Sepe, Immacolata |e verfasserin |4 aut | |
700 | 1 | |a De Santis, Mario |e verfasserin |4 aut | |
700 | 1 | |a Ciacci, Carolina |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al. |d 2001 |g 19(2019), 3 vom: 01. Apr., Seite 409-413 |w (DE-627)NLM119887509 |x 1424-3911 |7 nnns |
773 | 1 | 8 | |g volume:19 |g year:2019 |g number:3 |g day:01 |g month:04 |g pages:409-413 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.pan.2019.03.003 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 19 |j 2019 |e 3 |b 01 |c 04 |h 409-413 |