Cardiovascular risk in 159 934 frequent blood donors while addressing the healthy donor effect
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: To investigate whether regular blood donation decreases cardiovascular risk.
METHODS: All 159 934 Dutch whole-blood donors with an active donation career of at least 10 years were categorised into sex-specific donation tertiles based on the number of donations during this 10-year qualification period. Cardiovascular endpoints were based on hospital discharge diagnoses and death certificates from Dutch Hospital Data and Statistics Netherlands and occurring after the 10-year qualification period. Cox regression was used to estimate the age-adjusted and starting year-adjusted hazard rate ratio (HRR).
RESULTS: Female high-frequency blood donors had a reduced cardiovascular morbidity (HRR=0.91, 95% CI 0.85 to 0.98) compared with low-frequency blood donors. No effect was observed in men (HRR=1.00, 95% CI 0.95 to 1.05). To rule out a residual healthy donor effect (HDE), additional sensitivity analyses using a 5-year qualification period were conducted. The results supported the absence of a residual HDE.
CONCLUSIONS: This study showed a protective effect of long-term, high-frequency blood donation against cardiovascular disease. This effect was only observed in women and not in men.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:105 |
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| Enthalten in: |
Heart (British Cardiac Society) - 105(2019), 16 vom: 14. Aug., Seite 1260-1265 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Peffer, Karlijn [VerfasserIn] |
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| Links: |
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| Themen: |
Blood donors |
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| Anmerkungen: |
Date Completed 10.06.2020 Date Revised 10.06.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/heartjnl-2018-314138 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294954600 |
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| 245 | 1 | 0 | |a Cardiovascular risk in 159 934 frequent blood donors while addressing the healthy donor effect |
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| 500 | |a Date Completed 10.06.2020 | ||
| 500 | |a Date Revised 10.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: To investigate whether regular blood donation decreases cardiovascular risk | ||
| 520 | |a METHODS: All 159 934 Dutch whole-blood donors with an active donation career of at least 10 years were categorised into sex-specific donation tertiles based on the number of donations during this 10-year qualification period. Cardiovascular endpoints were based on hospital discharge diagnoses and death certificates from Dutch Hospital Data and Statistics Netherlands and occurring after the 10-year qualification period. Cox regression was used to estimate the age-adjusted and starting year-adjusted hazard rate ratio (HRR) | ||
| 520 | |a RESULTS: Female high-frequency blood donors had a reduced cardiovascular morbidity (HRR=0.91, 95% CI 0.85 to 0.98) compared with low-frequency blood donors. No effect was observed in men (HRR=1.00, 95% CI 0.95 to 1.05). To rule out a residual healthy donor effect (HDE), additional sensitivity analyses using a 5-year qualification period were conducted. The results supported the absence of a residual HDE | ||
| 520 | |a CONCLUSIONS: This study showed a protective effect of long-term, high-frequency blood donation against cardiovascular disease. This effect was only observed in women and not in men | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a blood donors | |
| 650 | 4 | |a cardiac risk factors and prevention | |
| 650 | 4 | |a cardiovascular diseases | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a translational cardiovascular medicine | |
| 700 | 1 | |a den Heijer, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a de Kort, Wim L A M |e verfasserin |4 aut | |
| 700 | 1 | |a Verbeek, André L M |e verfasserin |4 aut | |
| 700 | 1 | |a Atsma, Femke |e verfasserin |4 aut | |
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