Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients
AIM: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients.
METHODS: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement.
RESULTS: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients.
CONCLUSION: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Immunotherapy - 11(2019), 6 vom: 15. Apr., Seite 473-482 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Matsuda, Masaya [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.03.2020 Date Revised 06.03.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.2217/imt-2018-0170 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294838546 |
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| 100 | 1 | |a Matsuda, Masaya |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Regulatory T and B cells in peripheral blood of subcutaneous immunotherapy-treated Japanese cedar pollinosis patients |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 06.03.2020 | ||
| 500 | |a Date Revised 06.03.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a AIM: The aim of this study was to clarify whether there are more regulatory T (Treg) and regulatory B (Breg) cells, and higher levels of IL-10-related transcription factors in subcutaneous immunotherapy (SCIT)-treated pollinosis patients than in non-SCIT-treated patients | ||
| 520 | |a METHODS: Japanese cedar pollinosis patients undergoing SCIT had received treatment for at least 2.8 years. Peripheral blood mononuclear cells were used for flow cytometer analyses and mRNA measurement | ||
| 520 | |a RESULTS: The numbers of type 1 regulatory T (Tr1)-like cells and Breg cells, and expression of E4BP4 mRNA by peripheral blood mononuclear cells in SCIT-treated patients were higher than those in non-SCIT-treated patients | ||
| 520 | |a CONCLUSION: Tr1-like cells, Breg cells and E4BP4 may be involved in the effectiveness of SCIT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 700 | 1 | |a Doi, Kana |e verfasserin |4 aut | |
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| 700 | 1 | |a Kikuoka, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Omura, Shuji |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshida, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Ayani, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Manabu |e verfasserin |4 aut | |
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| 700 | 1 | |a Inui, Takaki |e verfasserin |4 aut | |
| 700 | 1 | |a Kawata, Ryo |e verfasserin |4 aut | |
| 700 | 1 | |a Nabe, Takeshi |e verfasserin |4 aut | |
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