Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
Copyright © 2019 Elsevier B.V. All rights reserved..
BACKGROUND: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a large cohort of healthy recreational athletes.
METHODS: A total of 1002 recreational cyclists without known cardiovascular disease or medication, participating in a 91-km mountain bike race were included. Median age was 47 years and 78% were males. Blood samples were obtained 24 h prior to, and 3 and 24 h after the race.
RESULTS: Cardiac TnI concentrations increased markedly from baseline [1.9 (1.6-3.0) ng/L] to 3 h after the race [52.1 (32.4-91.8) ng/L], declining at 24 h after the race [9.9 (6.0-20.0) ng/L]. Similarly, cTnT increased from baseline [3.0 (3.0-4.2) ng/L] to 3 h after the race [35.6 (24.4-54.4) ng/L], followed by a decline at 24 h after the race [10.0 (6.9-15.6) ng/L]. The 99th percentile was exceeded at 3 h after the race in 84% (n = 842) of subjects using the cTnI assay and in 92% (n = 925) of study subjects using the cTnT assay. Shorter race duration and higher systolic blood pressure (SBP) at baseline were highly significant (p < 0.001) independent predictors of exercise-induced cTn increase both in bivariate and multivariable analysis. The age, gender, body mass index, training experience and cardiovascular risk of participants were found to be less consistent predictors.
CONCLUSION: Systolic blood pressure and race duration were consistent predictors of the exercise-induced cTn increase. These variables likely reflect important mechanisms involved in the exercise-induced cTn elevation.
TRIAL REGISTRATION NUMBER: NCT02166216 https://clinicaltrials.gov/ct2/show/NCT02166216.
Errataetall: |
CommentIn: Int J Cardiol. 2019 Aug 1;288:19-21. - PMID 30955876 |
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Medienart: |
E-Artikel |
Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:283 |
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Enthalten in: |
International journal of cardiology - 283(2019) vom: 15. Mai, Seite 1-8 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Kleiven, Øyunn [VerfasserIn] |
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Links: |
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Themen: |
Biomarkers |
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Anmerkungen: |
Date Completed 23.12.2019 Date Revised 23.12.2019 published: Print-Electronic ClinicalTrials.gov: NCT02166216 CommentIn: Int J Cardiol. 2019 Aug 1;288:19-21. - PMID 30955876 Citation Status MEDLINE |
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doi: |
10.1016/j.ijcard.2019.02.044 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM294660100 |
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500 | |a CommentIn: Int J Cardiol. 2019 Aug 1;288:19-21. - PMID 30955876 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
520 | |a BACKGROUND: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a large cohort of healthy recreational athletes | ||
520 | |a METHODS: A total of 1002 recreational cyclists without known cardiovascular disease or medication, participating in a 91-km mountain bike race were included. Median age was 47 years and 78% were males. Blood samples were obtained 24 h prior to, and 3 and 24 h after the race | ||
520 | |a RESULTS: Cardiac TnI concentrations increased markedly from baseline [1.9 (1.6-3.0) ng/L] to 3 h after the race [52.1 (32.4-91.8) ng/L], declining at 24 h after the race [9.9 (6.0-20.0) ng/L]. Similarly, cTnT increased from baseline [3.0 (3.0-4.2) ng/L] to 3 h after the race [35.6 (24.4-54.4) ng/L], followed by a decline at 24 h after the race [10.0 (6.9-15.6) ng/L]. The 99th percentile was exceeded at 3 h after the race in 84% (n = 842) of subjects using the cTnI assay and in 92% (n = 925) of study subjects using the cTnT assay. Shorter race duration and higher systolic blood pressure (SBP) at baseline were highly significant (p < 0.001) independent predictors of exercise-induced cTn increase both in bivariate and multivariable analysis. The age, gender, body mass index, training experience and cardiovascular risk of participants were found to be less consistent predictors | ||
520 | |a CONCLUSION: Systolic blood pressure and race duration were consistent predictors of the exercise-induced cTn increase. These variables likely reflect important mechanisms involved in the exercise-induced cTn elevation | ||
520 | |a TRIAL REGISTRATION NUMBER: NCT02166216 https://clinicaltrials.gov/ct2/show/NCT02166216 | ||
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700 | 1 | |a Skadberg, Øyvind |e verfasserin |4 aut | |
700 | 1 | |a Melberg, Tor Harald |e verfasserin |4 aut | |
700 | 1 | |a Bjørkavoll-Bergseth, Magnus Friestad |e verfasserin |4 aut | |
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