Social evolution of innate immunity evasion in a virus
Antiviral immunity has been studied extensively from the perspective of virus-cell interactions, yet the role of virus-virus interactions remains poorly addressed. Here, we demonstrate that viral escape from interferon (IFN)-based innate immunity is a social process in which IFN-stimulating viruses determine the fitness of neighbouring viruses. We propose a general and simple social evolution framework to analyse how natural selection acts on IFN shutdown and validate it in cell cultures and mice infected with vesicular stomatitis virus. Furthermore, we find that IFN shutdown is costly because it reduces short-term viral progeny production, thus fulfilling the definition of an altruistic trait. Hence, in well-mixed populations, the IFN-blocking wild-type virus is susceptible to invasion by IFN-stimulating variants and spatial structure consequently determines whether IFN shutdown can evolve. Our findings reveal that fundamental social evolution rules govern viral innate immunity evasion and virulence and suggest possible antiviral interventions.
| Errataetall: |
CommentIn: Nat Microbiol. 2019 Jun;4(6):910-911. - PMID 31118503 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
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| Enthalten in: |
Nature microbiology - 4(2019), 6 vom: 04. Juni, Seite 1006-1013 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Domingo-Calap, Pilar [VerfasserIn] |
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| Links: |
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| Themen: |
9008-11-1 |
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| Anmerkungen: |
Date Completed 25.07.2019 Date Revised 29.01.2022 published: Print-Electronic CommentIn: Nat Microbiol. 2019 Jun;4(6):910-911. - PMID 31118503 Citation Status MEDLINE |
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| doi: |
10.1038/s41564-019-0379-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294579036 |
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| 500 | |a CommentIn: Nat Microbiol. 2019 Jun;4(6):910-911. - PMID 31118503 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Antiviral immunity has been studied extensively from the perspective of virus-cell interactions, yet the role of virus-virus interactions remains poorly addressed. Here, we demonstrate that viral escape from interferon (IFN)-based innate immunity is a social process in which IFN-stimulating viruses determine the fitness of neighbouring viruses. We propose a general and simple social evolution framework to analyse how natural selection acts on IFN shutdown and validate it in cell cultures and mice infected with vesicular stomatitis virus. Furthermore, we find that IFN shutdown is costly because it reduces short-term viral progeny production, thus fulfilling the definition of an altruistic trait. Hence, in well-mixed populations, the IFN-blocking wild-type virus is susceptible to invasion by IFN-stimulating variants and spatial structure consequently determines whether IFN shutdown can evolve. Our findings reveal that fundamental social evolution rules govern viral innate immunity evasion and virulence and suggest possible antiviral interventions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 700 | 1 | |a Segredo-Otero, Ernesto |e verfasserin |4 aut | |
| 700 | 1 | |a Durán-Moreno, María |e verfasserin |4 aut | |
| 700 | 1 | |a Sanjuán, Rafael |e verfasserin |4 aut | |
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