Positive and Negative Effects of Antipsychotic Medication : An International Online Survey of 832 Recipients
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Antipsychotic medication is currently the treatment of choice for psychosis, but few studies directly survey the first-hand experience of recipients.
OBJECTIVE: To ascertain the experiences and opinions of an international sample of users of antipsychotic drugs, regarding positive and negative effects.
METHODS: An online direct-to-consumer questionnaire was completed by 832 users of antipsychotics, from 30 countries - predominantly USA, UK and Australia. This is the largest such sample to date.
RESULTS: Over half (56%) thought, the drugs reduced the problems they were prescribed for, but 27% thought they made them worse. Slightly less people found the drugs generally 'helpful' (41%) than found them 'unhelpful' (43%). While 35% reported that their 'quality of life' was 'improved', 54% reported that it was made 'worse'. The average number of adverse effects reported was 11, with an average of five at the 'severe' level. Fourteen effects were reported by 57% or more participants, most commonly: 'Drowsiness, feeling tired, sedation' (92%), 'Loss of motivation' (86%), 'Slowed thoughts' (86%), and 'Emotional numbing' (85%). Suicidality was reported to be a side effect by 58%. Older people reported particularly poor outcomes and high levels of adverse effects. Duration of treatment was unrelated to positive outcomes but significantly related to negative outcomes. Most respondents (70%) had tried to stop taking the drugs. The most common reasons people wanted to stop were the side effects (64%) and worries about long-term physical health (52%). Most (70%) did not recall being told anything at all about side effects.
CONCLUSION: Clinical implications are discussed, with a particular focus on the principles of informed consent, and involving patients in decision making about their own lives.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Current drug safety - 14(2019), 3 vom: 27., Seite 173-181 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Read, John [VerfasserIn] |
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| Links: |
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| Themen: |
Antipsychotic Agents |
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| Anmerkungen: |
Date Completed 12.02.2020 Date Revised 12.02.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1574886314666190301152734 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294515437 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Antipsychotic medication is currently the treatment of choice for psychosis, but few studies directly survey the first-hand experience of recipients | ||
| 520 | |a OBJECTIVE: To ascertain the experiences and opinions of an international sample of users of antipsychotic drugs, regarding positive and negative effects | ||
| 520 | |a METHODS: An online direct-to-consumer questionnaire was completed by 832 users of antipsychotics, from 30 countries - predominantly USA, UK and Australia. This is the largest such sample to date | ||
| 520 | |a RESULTS: Over half (56%) thought, the drugs reduced the problems they were prescribed for, but 27% thought they made them worse. Slightly less people found the drugs generally 'helpful' (41%) than found them 'unhelpful' (43%). While 35% reported that their 'quality of life' was 'improved', 54% reported that it was made 'worse'. The average number of adverse effects reported was 11, with an average of five at the 'severe' level. Fourteen effects were reported by 57% or more participants, most commonly: 'Drowsiness, feeling tired, sedation' (92%), 'Loss of motivation' (86%), 'Slowed thoughts' (86%), and 'Emotional numbing' (85%). Suicidality was reported to be a side effect by 58%. Older people reported particularly poor outcomes and high levels of adverse effects. Duration of treatment was unrelated to positive outcomes but significantly related to negative outcomes. Most respondents (70%) had tried to stop taking the drugs. The most common reasons people wanted to stop were the side effects (64%) and worries about long-term physical health (52%). Most (70%) did not recall being told anything at all about side effects | ||
| 520 | |a CONCLUSION: Clinical implications are discussed, with a particular focus on the principles of informed consent, and involving patients in decision making about their own lives | ||
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