Treatment with Paracetamol is not Associated with Increased Airway Sensitivity and Risk of Asthma in Rats
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Some studies have linked the use of paracetamol (PAR) with adverse effects like wheezing, exacerbation of asthma symptoms and other respiratory problems. Other studies are inconclusive or deny this correlation. This makes the association between PAR and airway hypersensitivity very controversial and still under debate.
OBJECTIVE: This work investigated if chronic treatment with PAR in rats could directly affect the contraction and relaxation for different stimulus in isolated airways.
METHODS: Rats were treated for 2 weeks with PAR (400 mg/Kg, v.o.). The blood was collected for biochemical analysis (alanine aminotransferase (ALT), aspartate aminotransferase (AST), TBARs reaction and glutathione) and isolated tracheal rings were prepared in organ bath to measure isometric tone after contractile and relaxant stimulus.
RESULTS: Hepatic enzymes (ALT, AST) and lipid peroxidation were increased after PAR-treatment, while glutathione was decreased. Rats do not present any alteration in airway myocytes responsiveness, either to contractile or relaxant stimulus (i.e. cholinergic agonist, membrane depolarization, Ca2+ influx across sarcolemma, internal Ca2+ release from sarcoplasmic reticulum, Ca2+ channel blocking, β-agonist and NOmediating relaxation).
CONCLUSION: Despite increased oxidative stress and reduced antioxidant defense, chronic treatment with PAR does not induce airway hypersensitivity or risk of asthma in rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Current drug safety - 14(2019), 2 vom: 26., Seite 109-115 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lacerda Ribeiro, Marco Túlio [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.01.2020 Date Revised 06.01.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1574886314666190222194841 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294311084 |
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| 100 | 1 | |a Lacerda Ribeiro, Marco Túlio |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Treatment with Paracetamol is not Associated with Increased Airway Sensitivity and Risk of Asthma in Rats |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Revised 06.01.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Some studies have linked the use of paracetamol (PAR) with adverse effects like wheezing, exacerbation of asthma symptoms and other respiratory problems. Other studies are inconclusive or deny this correlation. This makes the association between PAR and airway hypersensitivity very controversial and still under debate | ||
| 520 | |a OBJECTIVE: This work investigated if chronic treatment with PAR in rats could directly affect the contraction and relaxation for different stimulus in isolated airways | ||
| 520 | |a METHODS: Rats were treated for 2 weeks with PAR (400 mg/Kg, v.o.). The blood was collected for biochemical analysis (alanine aminotransferase (ALT), aspartate aminotransferase (AST), TBARs reaction and glutathione) and isolated tracheal rings were prepared in organ bath to measure isometric tone after contractile and relaxant stimulus | ||
| 520 | |a RESULTS: Hepatic enzymes (ALT, AST) and lipid peroxidation were increased after PAR-treatment, while glutathione was decreased. Rats do not present any alteration in airway myocytes responsiveness, either to contractile or relaxant stimulus (i.e. cholinergic agonist, membrane depolarization, Ca2+ influx across sarcolemma, internal Ca2+ release from sarcoplasmic reticulum, Ca2+ channel blocking, β-agonist and NOmediating relaxation) | ||
| 520 | |a CONCLUSION: Despite increased oxidative stress and reduced antioxidant defense, chronic treatment with PAR does not induce airway hypersensitivity or risk of asthma in rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ALT | |
| 650 | 4 | |a AST | |
| 650 | 4 | |a BAL | |
| 650 | 4 | |a Paracetamol | |
| 650 | 4 | |a airways responsiveness | |
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| 700 | 1 | |a de Oliveira, Daniel Fernandes |e verfasserin |4 aut | |
| 700 | 1 | |a da Silva Castro, Patrícia Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Rocha, Matheus Lavorenti |e verfasserin |4 aut | |
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