Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America..
BACKGROUND: Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies.
METHODS: Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific effective reproductive numbers (Re). Discrete trait analysis (DTA) was used to quantify mixing among transmission groups.
RESULTS: We identified 5 subtype B Portuguese clades (26-79 sequences) and a large monophyletic subtype G Portuguese clade (236 sequences). We estimated that major shifts in HIV-1 transmission occurred around 1999 (95% Bayesian credible interval [BCI], 1998-2000) and 2000 (95% BCI, 1998-2001) for subtypes B and G, respectively. For subtype B, Re dropped from 1.91 (95% BCI, 1.73-2.09) to 0.62 (95% BCI,.52-.72). For subtype G, Re decreased from 1.49 (95% BCI, 1.39-1.59) to 0.72 (95% BCI, .63-.8). The DTA suggests that people who inject drugs (PWID) and heterosexuals were the source of most (>80%) virus lineage transitions for subtypes G and B, respectively.
CONCLUSIONS: The estimated declines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of harm reduction for PWID. Inferred transmission events across transmission groups emphasize the importance of prevention efforts for bridging populations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:220 |
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| Enthalten in: |
The Journal of infectious diseases - 220(2019), 2 vom: 19. Juni, Seite 233-243 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vasylyeva, Tetyana I [VerfasserIn] |
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| Links: |
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| Themen: |
Epidemiology |
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| Anmerkungen: |
Date Completed 24.02.2020 Date Revised 20.06.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiz085 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294304010 |
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| 100 | 1 | |a Vasylyeva, Tetyana I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 24.02.2020 | ||
| 500 | |a Date Revised 20.06.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. | ||
| 520 | |a BACKGROUND: Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies | ||
| 520 | |a METHODS: Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific effective reproductive numbers (Re). Discrete trait analysis (DTA) was used to quantify mixing among transmission groups | ||
| 520 | |a RESULTS: We identified 5 subtype B Portuguese clades (26-79 sequences) and a large monophyletic subtype G Portuguese clade (236 sequences). We estimated that major shifts in HIV-1 transmission occurred around 1999 (95% Bayesian credible interval [BCI], 1998-2000) and 2000 (95% BCI, 1998-2001) for subtypes B and G, respectively. For subtype B, Re dropped from 1.91 (95% BCI, 1.73-2.09) to 0.62 (95% BCI,.52-.72). For subtype G, Re decreased from 1.49 (95% BCI, 1.39-1.59) to 0.72 (95% BCI, .63-.8). The DTA suggests that people who inject drugs (PWID) and heterosexuals were the source of most (>80%) virus lineage transitions for subtypes G and B, respectively | ||
| 520 | |a CONCLUSIONS: The estimated declines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of harm reduction for PWID. Inferred transmission events across transmission groups emphasize the importance of prevention efforts for bridging populations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Portugal | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a harm reduction | |
| 650 | 4 | |a phylodynamics | |
| 650 | 4 | |a reproductive number | |
| 650 | 4 | |a transmission groups | |
| 650 | 7 | |a pol Gene Products, Human Immunodeficiency Virus |2 NLM | |
| 700 | 1 | |a du Plessis, Louis |e verfasserin |4 aut | |
| 700 | 1 | |a Pineda-Peña, Andrea C |e verfasserin |4 aut | |
| 700 | 1 | |a Kühnert, Denise |e verfasserin |4 aut | |
| 700 | 1 | |a Lemey, Philippe |e verfasserin |4 aut | |
| 700 | 1 | |a Vandamme, Anne-Mieke |e verfasserin |4 aut | |
| 700 | 1 | |a Gomes, Perpétua |e verfasserin |4 aut | |
| 700 | 1 | |a Camacho, Ricardo J |e verfasserin |4 aut | |
| 700 | 1 | |a Pybus, Oliver G |e verfasserin |4 aut | |
| 700 | 1 | |a Abecasis, Ana B |e verfasserin |4 aut | |
| 700 | 1 | |a Faria, Nuno R |e verfasserin |4 aut | |
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