Anti-inflammatory Effect of Woodfordia fructicosa Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis.
METHODS: In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund's adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni's test was used for statistical analysis.
RESULTS: WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed.
CONCLUSION: These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Anti-inflammatory & anti-allergy agents in medicinal chemistry - 19(2020), 2 vom: 01., Seite 103-112 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Raj, Hem [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.01.2021 Date Revised 22.01.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1871523018666190222120127 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294246584 |
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| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis | ||
| 520 | |a METHODS: In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund's adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni's test was used for statistical analysis | ||
| 520 | |a RESULTS: WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed | ||
| 520 | |a CONCLUSION: These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Arthritis | |
| 650 | 4 | |a Woodfordia fructicosa | |
| 650 | 4 | |a carrageenan | |
| 650 | 4 | |a ethanolic extract | |
| 650 | 4 | |a freund's adjuvant induced | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a monosodiumiodo acetate | |
| 650 | 4 | |a paw edema | |
| 650 | 4 | |a tumor necrosis factor. | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
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| 650 | 7 | |a Ethanol |2 NLM | |
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| 700 | 1 | |a Upmanyu, Neeraj |e verfasserin |4 aut | |
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