Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018
Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Emerging infectious diseases - 25(2019), 3 vom: 21. März, Seite 425-433 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sridhar, Siddharth [VerfasserIn] |
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| Links: |
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| Themen: |
China |
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| Anmerkungen: |
Date Completed 15.08.2019 Date Revised 02.02.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.3201/eid2503.181563 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM294142436 |
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| 520 | |a Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients | ||
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| 700 | 1 | |a Yip, Cyril C Y |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Shusheng |e verfasserin |4 aut | |
| 700 | 1 | |a Lo, Anthony W I |e verfasserin |4 aut | |
| 700 | 1 | |a Leung, Kit-Hang |e verfasserin |4 aut | |
| 700 | 1 | |a Mak, Winger W N |e verfasserin |4 aut | |
| 700 | 1 | |a Cai, Jianpiao |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Jasper F W |e verfasserin |4 aut | |
| 700 | 1 | |a Lau, Susanna K P |e verfasserin |4 aut | |
| 700 | 1 | |a Woo, Patrick C Y |e verfasserin |4 aut | |
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| 700 | 1 | |a Kwan, Tze-Hoi |e verfasserin |4 aut | |
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| 700 | 1 | |a Wong, Sally C Y |e verfasserin |4 aut | |
| 700 | 1 | |a Yuen, Kwok-Yung |e verfasserin |4 aut | |
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