Cancer and microbiota in elderly patients : challenges and management
Aging is a major risk factor of cancers. In recent years, several studies highlighted a change in the diversity and the abundance of the intestinal microbiota associated with aging. Moreover, epidemiological studies, experimental and clinical studies have suggested that the microbiota is implicated in cancer physiopathology and could modulate the efficacy and the tolerance of oncological treatments, for example the incidence of gastrointestinal toxicity and infectious disease. In this review, our objective was first to described the main studies that have focused on the composition of the microbiota associated with aging, cancer and during cancer therapies. Second, we discussed challenges and perspectives on cancer management and research, in elderly patients. Finally, we assume that further studies will confirm that the composition of the intestinal microbiota could be considered as a biomarker of frailty that could be used to optimize cancer management in elderly patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Geriatrie et psychologie neuropsychiatrie du vieillissement - 17(2019), 1 vom: 01. März, Seite 20-30 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Apport de l’analyse du microbiote intestinal pour améliorer la prise en charge oncologique chez le sujet âgé |
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| Beteiligte Personen: |
Chapelet, Guillaume [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 20.08.2019 Date Revised 08.01.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1684/pnv.2019.0783 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM293875820 |
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| 520 | |a Aging is a major risk factor of cancers. In recent years, several studies highlighted a change in the diversity and the abundance of the intestinal microbiota associated with aging. Moreover, epidemiological studies, experimental and clinical studies have suggested that the microbiota is implicated in cancer physiopathology and could modulate the efficacy and the tolerance of oncological treatments, for example the incidence of gastrointestinal toxicity and infectious disease. In this review, our objective was first to described the main studies that have focused on the composition of the microbiota associated with aging, cancer and during cancer therapies. Second, we discussed challenges and perspectives on cancer management and research, in elderly patients. Finally, we assume that further studies will confirm that the composition of the intestinal microbiota could be considered as a biomarker of frailty that could be used to optimize cancer management in elderly patients | ||
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| 700 | 1 | |a Batard, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Lepelletier, Didier |e verfasserin |4 aut | |
| 700 | 1 | |a Berrut, Gilles |e verfasserin |4 aut | |
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