Cerebellar Dysfunction in an Elderly Male After a Brief Course of Metronidazole

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BACKGROUND: Metronidazole, a widely used antibacterial and antiprotozoal drug, is often the drug of choice in amoebic liver abscess. The drug, otherwise safe, can cause serious central nervous disturbances in rare circumstances.

CASE REPORT: Here, we report a case of cerebellar dysfunction in the form of slurring of speech and episodes of falls, in an elderly male following a three-week course of metronidazole therapy.

RESULTS AND CONCLUSION: The patient manifested classic radiologic features of metronidazole neurotoxicity. Marked improvement in clinical symptoms was seen following drug discontinuation.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:14

Enthalten in:

Current drug safety - 14(2019), 2 vom: 22., Seite 163-166

Sprache:

Englisch

Beteiligte Personen:

Kaur, Upinder [VerfasserIn]
Kumar, Ishan [VerfasserIn]
Singh, Anup [VerfasserIn]
Kumar, Mukesh [VerfasserIn]
Chakrabarti, Sankha Shubhra [VerfasserIn]

Links:

Volltext

Themen:

140QMO216E
Amoebiasis
Anti-Bacterial Agents
CSF
Case Reports
Metronidazole
Neurotoxicity
Nitro imidazole
Pharmacogenetics
Pharmacovigilance.

Anmerkungen:

Date Completed 09.12.2019

Date Revised 17.12.2019

published: Print

Citation Status MEDLINE

doi:

10.2174/1574886314666190206154735

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM293540128