mTOR Is Key to T Cell Transdifferentiation
Copyright © 2019 Elsevier Inc. All rights reserved..
T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity.
| Errataetall: |
CommentOn: Nature. 2019 Jan;565(7737):101-105. - PMID 30568299 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Cell metabolism - 29(2019), 2 vom: 05. Feb., Seite 241-242 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yan, Jiawei [VerfasserIn] |
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| Links: |
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| Themen: |
Comment |
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| Anmerkungen: |
Date Completed 08.11.2019 Date Revised 31.05.2022 published: Print CommentOn: Nature. 2019 Jan;565(7737):101-105. - PMID 30568299 Citation Status MEDLINE |
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| doi: |
10.1016/j.cmet.2019.01.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM293528594 |
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| 520 | |a T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity | ||
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