CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques
© 2019 The Authors. Journal of Medical Primatology Published by John Wiley & Sons Ltd..
BACKGROUND: Tuberculosis (TB) kills millions of people every year. CD4 and CD8 T cells are critical in the immune response against TB. T cells expressing both CD4 and CD8 (CD4CD8 T cells) are functionally active and have not been examined in the context of TB.
METHODS: We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during Mycobacterium tuberculosis (Mtb) infection.
RESULTS: CD4CD8 T cells increase in frequency during early Mtb infection in PBMC and BAL from pre-infection. Peripheral, airway, and lung granuloma CD4CD8 T cells have distinct patterns and greater cytokine production than CD4 or CD8 T cells.
CONCLUSION: Our data suggest that CD4CD8 T cells transient the blood and airways early during infection to reach the granulomas where they are involved directly in the host response to Mtb.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Journal of medical primatology - 48(2019), 2 vom: 15. Apr., Seite 82-89 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Diedrich, Collin Richard [VerfasserIn] |
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| Links: |
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| Themen: |
CD4CD8 |
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| Anmerkungen: |
Date Completed 15.04.2020 Date Revised 09.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/jmp.12399 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM293505268 |
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| 100 | 1 | |a Diedrich, Collin Richard |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a CD4CD8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 15.04.2020 | ||
| 500 | |a Date Revised 09.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019 The Authors. Journal of Medical Primatology Published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: Tuberculosis (TB) kills millions of people every year. CD4 and CD8 T cells are critical in the immune response against TB. T cells expressing both CD4 and CD8 (CD4CD8 T cells) are functionally active and have not been examined in the context of TB | ||
| 520 | |a METHODS: We examine peripheral blood mononuclear cells (PBMC) and bronchoalveolar lavage cells (BAL) and lung granulomas from 28 cynomolgus macaques during Mycobacterium tuberculosis (Mtb) infection | ||
| 520 | |a RESULTS: CD4CD8 T cells increase in frequency during early Mtb infection in PBMC and BAL from pre-infection. Peripheral, airway, and lung granuloma CD4CD8 T cells have distinct patterns and greater cytokine production than CD4 or CD8 T cells | ||
| 520 | |a CONCLUSION: Our data suggest that CD4CD8 T cells transient the blood and airways early during infection to reach the granulomas where they are involved directly in the host response to Mtb | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a CD4CD8 | |
| 650 | 4 | |a T cells | |
| 650 | 4 | |a mycobacteria | |
| 650 | 4 | |a tuberculosis | |
| 700 | 1 | |a Gideon, Hannah Priyadarshini |e verfasserin |4 aut | |
| 700 | 1 | |a Rutledge, Tara |e verfasserin |4 aut | |
| 700 | 1 | |a Baranowski, Tonilynn Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Maiello, Pauline |e verfasserin |4 aut | |
| 700 | 1 | |a Myers, Amy J |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Philana Ling |e verfasserin |4 aut | |
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