Abnormal cerebellar connectivity and plasticity in isolated cervical dystonia
There is increasing evidence that supports the role of the cerebellum in the pathophysiology of dystonia. We used transcranial magnetic stimulation to test the hypothesis that patients with cervical dystonia may have a disrupted cerebellar cortical connectivity at rest, and that cerebellar plasticity is altered too. We enrolled 12 patients with isolated cervical dystonia and 13 controls. A paired-pulse transcranial magnetic stimulation protocol was applied over the right cerebellum and the left primary motor area. Changes in the amplitude of motor evoked potentials were analysed. Continuous and intermittent Theta Burst Stimulation over the cerebellum was also applied. The effects of these repetitive protocols on cortical excitability, on intra-cortical circuits and on cerebellar cortical inhibition were analysed. In healthy subjects, but not in dystonic patients, a conditioning stimulus over the cerebellum was able to inhibit the amplitude of the motor evoked potentials from primary motor cortex. In healthy subjects continuous and intermittent cerebellar Theta Burst Stimulation were able to decrease and increase respectively motor cortex excitability. Continuous Theta Burst Stimulation was able to abolish the cerebellar cortical inhibition observed in basal condition. These effects were not observed in patients with cervical dystonia. Cerebellar cortical connectivity and cerebellar plasticity is altered at rest in patients with cervical dystonia.
| Errataetall: |
CommentIn: J Neurol. 2019 Jun;266(6):1549-1551. - PMID 31037418 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
PloS one - 14(2019), 1 vom: 01., Seite e0211367 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Porcacchia, Paolo [VerfasserIn] |
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| Anmerkungen: |
Date Completed 24.10.2019 Date Revised 09.03.2020 published: Electronic-eCollection CommentIn: J Neurol. 2019 Jun;266(6):1549-1551. - PMID 31037418 Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0211367 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM293095140 |
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| 245 | 1 | 0 | |a Abnormal cerebellar connectivity and plasticity in isolated cervical dystonia |
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| 500 | |a CommentIn: J Neurol. 2019 Jun;266(6):1549-1551. - PMID 31037418 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a There is increasing evidence that supports the role of the cerebellum in the pathophysiology of dystonia. We used transcranial magnetic stimulation to test the hypothesis that patients with cervical dystonia may have a disrupted cerebellar cortical connectivity at rest, and that cerebellar plasticity is altered too. We enrolled 12 patients with isolated cervical dystonia and 13 controls. A paired-pulse transcranial magnetic stimulation protocol was applied over the right cerebellum and the left primary motor area. Changes in the amplitude of motor evoked potentials were analysed. Continuous and intermittent Theta Burst Stimulation over the cerebellum was also applied. The effects of these repetitive protocols on cortical excitability, on intra-cortical circuits and on cerebellar cortical inhibition were analysed. In healthy subjects, but not in dystonic patients, a conditioning stimulus over the cerebellum was able to inhibit the amplitude of the motor evoked potentials from primary motor cortex. In healthy subjects continuous and intermittent cerebellar Theta Burst Stimulation were able to decrease and increase respectively motor cortex excitability. Continuous Theta Burst Stimulation was able to abolish the cerebellar cortical inhibition observed in basal condition. These effects were not observed in patients with cervical dystonia. Cerebellar cortical connectivity and cerebellar plasticity is altered at rest in patients with cervical dystonia | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Álvarez de Toledo, Paloma |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Baena, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Martín-Rodríguez, Juan Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Palomar, Francisco J |e verfasserin |4 aut | |
| 700 | 1 | |a Vargas-González, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Jesús, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Koch, Giacomo |e verfasserin |4 aut | |
| 700 | 1 | |a Mir, Pablo |e verfasserin |4 aut | |
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