Advances in curcumin-loaded nanopreparations : improving bioavailability and overcoming inherent drawbacks
Curcumin (CUR), one of the major extracts of turmeric, has gained extensive attention owing to its extraordinary benefits as anti-cancer, anti-bacterial, anti-ulcerative, anti-depressant, anti-inflammatory and wound healing agent. However, a major barrier in its application lies in its inherent nature of low water solubility, instability, and short half-life. Different strategies have been adopted to overcome these barriers like preparing nano-sized formulations and exploiting stable and hydrophilic derivatives, and collaborative drug delivery. Nanopreparations could maintain the pharmacological effect of drugs, even the holistic effects of drug extracts. In addition, nanopreparations based on novel materials make it a reality to regulate the drug release rate according to the various environmental conditions. The therapeutic applications and novel investigated nanopreparations of CUR for prevention and treatment of various diseases, especially, cancer and inflammatory disorders are discussed in this review.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Journal of drug targeting - 27(2019), 9 vom: 01. Nov., Seite 917-931 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Yanan [VerfasserIn] |
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| Links: |
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| Themen: |
Bioavailability |
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| Anmerkungen: |
Date Completed 13.08.2020 Date Revised 13.08.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/1061186X.2019.1572158 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292999143 |
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| 500 | |a Date Revised 13.08.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Curcumin (CUR), one of the major extracts of turmeric, has gained extensive attention owing to its extraordinary benefits as anti-cancer, anti-bacterial, anti-ulcerative, anti-depressant, anti-inflammatory and wound healing agent. However, a major barrier in its application lies in its inherent nature of low water solubility, instability, and short half-life. Different strategies have been adopted to overcome these barriers like preparing nano-sized formulations and exploiting stable and hydrophilic derivatives, and collaborative drug delivery. Nanopreparations could maintain the pharmacological effect of drugs, even the holistic effects of drug extracts. In addition, nanopreparations based on novel materials make it a reality to regulate the drug release rate according to the various environmental conditions. The therapeutic applications and novel investigated nanopreparations of CUR for prevention and treatment of various diseases, especially, cancer and inflammatory disorders are discussed in this review | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Review | |
| 650 | 4 | |a Curcumin | |
| 650 | 4 | |a bioavailability | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a liposomes | |
| 650 | 4 | |a micelles | |
| 650 | 4 | |a nanopreparations | |
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| 700 | 1 | |a Rauf Khan, Abdur |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Manfei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhai, Yujia |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Jianbo |e verfasserin |4 aut | |
| 700 | 1 | |a Bobrovskaya, Larisa |e verfasserin |4 aut | |
| 700 | 1 | |a Zhai, Guangxi |e verfasserin |4 aut | |
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