Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND AND OBJECTIVE: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats.
METHODS: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study.
RESULTS: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity.
CONCLUSION: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Cardiovascular & hematological agents in medicinal chemistry - 17(2019), 1 vom: 15., Seite 28-39 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ajebli, Mohammed [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.11.2019 Date Revised 11.12.2019 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1871525717666190121143934 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292945949 |
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| 245 | 1 | 0 | |a Flavonoid-Enriched Extract from Desert Plant Warionia saharae Improves Glucose and Cholesterol Levels in Diabetic Rats |
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| 500 | |a Date Revised 11.12.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND AND OBJECTIVE: Warionia saharae Benth and Coss, is a medicinal plant used for its anti-diabetic properties in Morocco. This study was designed to examine the effect of the Flavonoid- Enriched Extract (FEE) obtained from Warionia saharae (W. saharae) on glucose and lipid metabolism in normal and streptozotocin (STZ)-induced diabetic rats | ||
| 520 | |a METHODS: Acute (6 h) and sub-chronic (15 days) oral administration of FEE (10 mg/kg) was used to assess the glucose and lipid-lowering activity in normal and diabetic rats. Furthermore, glucose test tolerance, liver histopathological examination and in vitro antioxidant activity of FEE were carried out in this study | ||
| 520 | |a RESULTS: Results indicated that FEE was able to exert antihyperglycemic activity. Additionally, FEE improved histopathological status of liver and pancreas in diabetic rats and possessed antioxidant activity | ||
| 520 | |a CONCLUSION: In conclusion, the present investigation revealed that FEE had potent antidiabetic effect in diabetic rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antioxidant | |
| 650 | 4 | |a Warionia saharae | |
| 650 | 4 | |a diabetes | |
| 650 | 4 | |a flavonoid-enriched extract | |
| 650 | 4 | |a histopathology | |
| 650 | 4 | |a lipid profile. | |
| 650 | 7 | |a Antioxidants |2 NLM | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 650 | 7 | |a Flavonoids |2 NLM | |
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