Symptomatic involvement of the stomach and duodenum as initial presentation of AL amyloidosis
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ..
Primary systemic or amyloid light chain (AL) amyloidosis is a multisystem disorder with myriad presentations. Although it can involve the upper gastrointestinal tract in 8% of cases, symptomatic involvement is exceedingly rare. We chronicle here a case of postprandial epigastric pain associated with AL amyloidosis involving the stomach and duodenum. Pathological examination of endoscopic biopsy using Congo red staining confirmed the diagnosis. In order to establish the underlying aetiology of AL amyloidosis, the patient underwent extensive workup. Eventually, she was diagnosed with multiple myeloma based on the standard set of investigations. This paper underscores the importance of clinical suspicion of amyloidosis in patients presenting with non-specific gastrointestinal symptoms and highlights the role of endoscopic biopsy to confirm the amyloid deposition. Since gastrointestinal amyloidosis is a disease with a poor prognosis, early diagnosis and treatment are particularly warranted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
BMJ case reports - 12(2019), 1 vom: 17. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Inayat, Faisal [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 02.05.2019 Date Revised 17.01.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bcr-2018-227550 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292867484 |
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| 520 | |a © BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a Primary systemic or amyloid light chain (AL) amyloidosis is a multisystem disorder with myriad presentations. Although it can involve the upper gastrointestinal tract in 8% of cases, symptomatic involvement is exceedingly rare. We chronicle here a case of postprandial epigastric pain associated with AL amyloidosis involving the stomach and duodenum. Pathological examination of endoscopic biopsy using Congo red staining confirmed the diagnosis. In order to establish the underlying aetiology of AL amyloidosis, the patient underwent extensive workup. Eventually, she was diagnosed with multiple myeloma based on the standard set of investigations. This paper underscores the importance of clinical suspicion of amyloidosis in patients presenting with non-specific gastrointestinal symptoms and highlights the role of endoscopic biopsy to confirm the amyloid deposition. Since gastrointestinal amyloidosis is a disease with a poor prognosis, early diagnosis and treatment are particularly warranted | ||
| 650 | 4 | |a Case Reports | |
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| 650 | 4 | |a drugs: gastrointestinal system | |
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| 650 | 4 | |a general practice / family medicine | |
| 650 | 4 | |a haematology (incl blood transfusion) | |
| 650 | 4 | |a stomach and duodenum | |
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| 700 | 1 | |a Zahid, Effa |e verfasserin |4 aut | |
| 700 | 1 | |a Ali, Nouman Safdar |e verfasserin |4 aut | |
| 700 | 1 | |a Charles, Roger |e verfasserin |4 aut | |
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