A multicentric study on accurate grading of prostate cancer with systematic and MRI/US fusion targeted biopsies : comparison with final histopathology after radical prostatectomy
OBJECTIVE: To evaluate the accuracy in histologic grading of MRI/US image fusion biopsy by comparing histopathology between systematic biopsies (SB), targeted biopsies (TB) and the combination of both (SB + TB) with the final histopathologic outcomes of radical prostatectomy specimens.
MATERIALS AND METHODS: Retrospective, multicentric study of 443 patients who underwent SB and TB using MRI/US fusion technique (Urostation® and Trinity®) prior to radical prostatectomy between 2010 and 2017. Cochran's Q test and McNemar test were conducted as a post hoc test. Uni-multivariable analyses were performed on several clinic-pathological variables to analyze factors predicting histopathological concordance for targeted biopsies.
RESULTS: Concordance in ISUP (International Society of Urological Pathology) grade between SB, TB and SB + TB with final histopathology was 49.4%, 51.2%, and 63.2% for overall prostate cancer and 41.2%, 48.3%, and 56.7% for significant prostate cancer (ISUP grade ≥ 2), respectively. Significant difference in terms of concordance, downgrading and upgrading was found between SB and TB (ISUP grade ≥ 2 only), SB and SB + TB, TB and SB + TB (overall ISUP grade and ISUP grade ≥ 2) (p < 0.001). Total number of cores and previous biopsies were significant independent predictive factors for concordance with TB technique.
CONCLUSION: In this retrospective study, combination of SB and TB significantly increased concordance with final histopathology despite a limited additional number of cores needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
World journal of urology - 37(2019), 10 vom: 17. Okt., Seite 2109-2117 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Diamand, R [VerfasserIn] |
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| Links: |
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| Themen: |
Biopsy |
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| Anmerkungen: |
Date Completed 19.02.2020 Date Revised 09.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00345-019-02634-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292801068 |
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| 100 | 1 | |a Diamand, R |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A multicentric study on accurate grading of prostate cancer with systematic and MRI/US fusion targeted biopsies |b comparison with final histopathology after radical prostatectomy |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 19.02.2020 | ||
| 500 | |a Date Revised 09.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To evaluate the accuracy in histologic grading of MRI/US image fusion biopsy by comparing histopathology between systematic biopsies (SB), targeted biopsies (TB) and the combination of both (SB + TB) with the final histopathologic outcomes of radical prostatectomy specimens | ||
| 520 | |a MATERIALS AND METHODS: Retrospective, multicentric study of 443 patients who underwent SB and TB using MRI/US fusion technique (Urostation® and Trinity®) prior to radical prostatectomy between 2010 and 2017. Cochran's Q test and McNemar test were conducted as a post hoc test. Uni-multivariable analyses were performed on several clinic-pathological variables to analyze factors predicting histopathological concordance for targeted biopsies | ||
| 520 | |a RESULTS: Concordance in ISUP (International Society of Urological Pathology) grade between SB, TB and SB + TB with final histopathology was 49.4%, 51.2%, and 63.2% for overall prostate cancer and 41.2%, 48.3%, and 56.7% for significant prostate cancer (ISUP grade ≥ 2), respectively. Significant difference in terms of concordance, downgrading and upgrading was found between SB and TB (ISUP grade ≥ 2 only), SB and SB + TB, TB and SB + TB (overall ISUP grade and ISUP grade ≥ 2) (p < 0.001). Total number of cores and previous biopsies were significant independent predictive factors for concordance with TB technique | ||
| 520 | |a CONCLUSION: In this retrospective study, combination of SB and TB significantly increased concordance with final histopathology despite a limited additional number of cores needed | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Biopsy | |
| 650 | 4 | |a Concordance | |
| 650 | 4 | |a MRI/US fusion | |
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a Targeted | |
| 700 | 1 | |a Oderda, M |e verfasserin |4 aut | |
| 700 | 1 | |a Al Hajj Obeid, W |e verfasserin |4 aut | |
| 700 | 1 | |a Albisinni, S |e verfasserin |4 aut | |
| 700 | 1 | |a Van Velthoven, R |e verfasserin |4 aut | |
| 700 | 1 | |a Fasolis, G |e verfasserin |4 aut | |
| 700 | 1 | |a Simone, G |e verfasserin |4 aut | |
| 700 | 1 | |a Ferriero, M |e verfasserin |4 aut | |
| 700 | 1 | |a Roche, J-B |e verfasserin |4 aut | |
| 700 | 1 | |a Piechaud, T |e verfasserin |4 aut | |
| 700 | 1 | |a Pastore, A |e verfasserin |4 aut | |
| 700 | 1 | |a Carbone, A |e verfasserin |4 aut | |
| 700 | 1 | |a Fiard, G |e verfasserin |4 aut | |
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| 700 | 1 | |a Papalia, R |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, P |e verfasserin |4 aut | |
| 700 | 1 | |a Eldred-Evans, D |e verfasserin |4 aut | |
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| 700 | 1 | |a Peltier, A |e verfasserin |4 aut | |
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