Role of Adiponectin in prostate cancer
Copyright® by the International Brazilian Journal of Urology..
Obesity is defined as a chronic and excessive growth of adipose tissue. It has been associated with a high risk for development and progression of obesity-associated malignancies, while adipokines may mediate this association. Adiponectin is an adipose tissue-derived adipokines, with significant anti-diabetic, anti-inflammatory, anti-atherosclerotic and anti-proliferative properties. Plasma adiponectin levels are decreased in obese individuals, and this feature is closely correlated with development of several metabolic, immunological and neoplastic diseases. Recent studies have shown that prostate cancer patients have lower serum adiponectin levels and decreased expression of adiponectin receptors in tumor tissues, which suggests plasma adiponectin level is a risk factor for prostate cancer. Furthermore, exogenous adiponectin has exhibited therapeutic potential in animal models. In this review, we focus on the potential role of adiponectin and the underlying mechanism of adiponectin in the development and progression of prostate cancer. Exploring the signaling pathways linking adiponectin with tumorigenesis might provide a potential target for therapy.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
|---|---|
| Enthalten in: |
International braz j urol : official journal of the Brazilian Society of Urology - 45(2019), 2 vom: 15. März, Seite 220-228 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Hu, Xiaobo [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Adiponectin |
|---|
| Anmerkungen: |
Date Completed 26.07.2019 Date Revised 25.02.2020 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1590/S1677-5538.IBJU.2018.0261 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM292767773 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM292767773 | ||
| 003 | DE-627 | ||
| 005 | 20231225073837.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1590/S1677-5538.IBJU.2018.0261 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0975.xml |
| 035 | |a (DE-627)NLM292767773 | ||
| 035 | |a (NLM)30648824 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Hu, Xiaobo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Role of Adiponectin in prostate cancer |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.07.2019 | ||
| 500 | |a Date Revised 25.02.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright® by the International Brazilian Journal of Urology. | ||
| 520 | |a Obesity is defined as a chronic and excessive growth of adipose tissue. It has been associated with a high risk for development and progression of obesity-associated malignancies, while adipokines may mediate this association. Adiponectin is an adipose tissue-derived adipokines, with significant anti-diabetic, anti-inflammatory, anti-atherosclerotic and anti-proliferative properties. Plasma adiponectin levels are decreased in obese individuals, and this feature is closely correlated with development of several metabolic, immunological and neoplastic diseases. Recent studies have shown that prostate cancer patients have lower serum adiponectin levels and decreased expression of adiponectin receptors in tumor tissues, which suggests plasma adiponectin level is a risk factor for prostate cancer. Furthermore, exogenous adiponectin has exhibited therapeutic potential in animal models. In this review, we focus on the potential role of adiponectin and the underlying mechanism of adiponectin in the development and progression of prostate cancer. Exploring the signaling pathways linking adiponectin with tumorigenesis might provide a potential target for therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a Prostatic Neoplasms | |
| 650 | 4 | |a Stress, Physiological | |
| 650 | 7 | |a Adiponectin |2 NLM | |
| 650 | 7 | |a Receptors, Adiponectin |2 NLM | |
| 700 | 1 | |a Hu, Cong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Caiping |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Long, Shiyin |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Zhaohui |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International braz j urol : official journal of the Brazilian Society of Urology |d 2002 |g 45(2019), 2 vom: 15. März, Seite 220-228 |w (DE-627)NLM152735291 |x 1677-6119 |7 nnns |
| 773 | 1 | 8 | |g volume:45 |g year:2019 |g number:2 |g day:15 |g month:03 |g pages:220-228 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0261 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 45 |j 2019 |e 2 |b 15 |c 03 |h 220-228 | ||