Pain : Persistent postsurgery and bone cancer-related pain
The generation of neuropathic pain is a complex dynamic process. Factors involved include one or more dysregulated sensory neural pathways; dysregulated activity of specific neurotransmitters, synapses, receptors and cognitive and emotional neural circuits; and the balance between degenerative and regenerative neural events. Risk factors include age, sex, cognition, emotions, genetic polymorphism, previous or ongoing chronic pain conditions and the use of certain drugs. Intense pain experienced before, during and after surgery is a risk factor for the development of central sensitization with consequent persistent postsurgery neuropathic pain. Blockade of N-methyl-D-aspartate receptors with appropriate drugs during and immediately after surgery may prevent persistent postsurgical pain. Most cancers, but particularly malignant metastases in bone, can induce persistent pain. Local factors including direct damage to sensory nerve fibres, infiltration of nerve roots by cancer cells and algogenic biological agents within the microenvironment of the tumour bring about central sensitization of dorsal horn neurons, characterized by neurochemical reorganization with persistent cancer pain. In this article, the clinical features, pathogenesis and principles of management of persistent postsurgery pain and cancer pain are briefly discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
The Journal of international medical research - 47(2019), 2 vom: 01. Feb., Seite 528-543 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Feller, Liviu [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.06.2019 Date Revised 25.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/0300060518818296 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292606753 |
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| 245 | 1 | 0 | |a Pain |b Persistent postsurgery and bone cancer-related pain |
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| 500 | |a Date Completed 11.06.2019 | ||
| 500 | |a Date Revised 25.02.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The generation of neuropathic pain is a complex dynamic process. Factors involved include one or more dysregulated sensory neural pathways; dysregulated activity of specific neurotransmitters, synapses, receptors and cognitive and emotional neural circuits; and the balance between degenerative and regenerative neural events. Risk factors include age, sex, cognition, emotions, genetic polymorphism, previous or ongoing chronic pain conditions and the use of certain drugs. Intense pain experienced before, during and after surgery is a risk factor for the development of central sensitization with consequent persistent postsurgery neuropathic pain. Blockade of N-methyl-D-aspartate receptors with appropriate drugs during and immediately after surgery may prevent persistent postsurgical pain. Most cancers, but particularly malignant metastases in bone, can induce persistent pain. Local factors including direct damage to sensory nerve fibres, infiltration of nerve roots by cancer cells and algogenic biological agents within the microenvironment of the tumour bring about central sensitization of dorsal horn neurons, characterized by neurochemical reorganization with persistent cancer pain. In this article, the clinical features, pathogenesis and principles of management of persistent postsurgery pain and cancer pain are briefly discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Inflammatory pain | |
| 650 | 4 | |a bone cancer pain | |
| 650 | 4 | |a metastatic jaw cancer | |
| 650 | 4 | |a metastatic spinal cord compression | |
| 650 | 4 | |a neuropathic pain | |
| 650 | 4 | |a oral squamous cell carcinoma | |
| 650 | 4 | |a persistent postsurgery pain | |
| 650 | 4 | |a procedural pain | |
| 700 | 1 | |a Khammissa, Razia Abdool Gafaar |e verfasserin |4 aut | |
| 700 | 1 | |a Bouckaert, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Ballyram, Raoul |e verfasserin |4 aut | |
| 700 | 1 | |a Jadwat, Yusuf |e verfasserin |4 aut | |
| 700 | 1 | |a Lemmer, Johan |e verfasserin |4 aut | |
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