Chemoprevention of Lung Carcinogenesis by Dietary Nicotinamide and Inhaled Budesonide
©2019 American Association for Cancer Research..
Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in the treatment of asthma, were evaluated to determine their individual and combinational chemopreventive efficacy on benzo(a)pyrene-induced lung tumors in female A/J mice. Nicotinamide fed at a dietary concentration of 0.75% significantly inhibited tumor multiplicity. Nicotinamide by aerosol inhalation at doses up to 15 mg/kg/day did not result in a statistically significant reduction in tumor multiplicity. Finally, dietary nicotinamide was administered with aerosol budesonide and tumor multiplicity reduced by 90% at 1 week and 49% at 8 weeks post last carcinogen dose. We conclude nicotinamide is an effective and safe agent for lung cancer dietary prevention at both early- and late-stage carcinogenesis and that efficacy is increased with aerosol budesonide. Combination chemoprevention with these agents is a well-tolerated and effective strategy which could be clinically advanced to human studies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Cancer prevention research (Philadelphia, Pa.) - 12(2019), 2 vom: 15. Feb., Seite 69-78 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Galbraith, Arthur R [VerfasserIn] |
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| Links: |
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| Themen: |
12001-76-2 |
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| Anmerkungen: |
Date Completed 14.04.2020 Date Revised 14.04.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1158/1940-6207.CAPR-17-0402 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292353839 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ©2019 American Association for Cancer Research. | ||
| 520 | |a Nicotinamide, the amide form of vitamin B3, and budesonide, a synthetic glucocorticoid used in the treatment of asthma, were evaluated to determine their individual and combinational chemopreventive efficacy on benzo(a)pyrene-induced lung tumors in female A/J mice. Nicotinamide fed at a dietary concentration of 0.75% significantly inhibited tumor multiplicity. Nicotinamide by aerosol inhalation at doses up to 15 mg/kg/day did not result in a statistically significant reduction in tumor multiplicity. Finally, dietary nicotinamide was administered with aerosol budesonide and tumor multiplicity reduced by 90% at 1 week and 49% at 8 weeks post last carcinogen dose. We conclude nicotinamide is an effective and safe agent for lung cancer dietary prevention at both early- and late-stage carcinogenesis and that efficacy is increased with aerosol budesonide. Combination chemoprevention with these agents is a well-tolerated and effective strategy which could be clinically advanced to human studies | ||
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| 700 | 1 | |a Wuertz, Beverly R |e verfasserin |4 aut | |
| 700 | 1 | |a Antonides, Jennifer D |e verfasserin |4 aut | |
| 700 | 1 | |a Steele, Vernon E |e verfasserin |4 aut | |
| 700 | 1 | |a Wattenberg, Lee W |e verfasserin |4 aut | |
| 700 | 1 | |a Ondrey, Frank G |e verfasserin |4 aut | |
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