Bioactive naphthoquinone and anthrone derivatives from endophytic Micromonospora sp. NEAU-gq13
Two new naphthalenone derivatives, 5-hydroxy-4-oxo-2-(2-oxopropyl)-1,2,3,4-tetrahydronaphthalen-1-yl acetate (1) and 5-hydroxy-2-(2-hydroxypropyl)naphthalene-1,4-dione (2), together with two new anthrone derivatives, (S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3) and 4,5-dihydroxy-2-methyl-9H-xanthen-9-one (4), were isolated from the fermentation broth of endophytic Micromonospora sp. NEAU-gq13. Their structures were determined by 1D-NMR, 2D-NMR, and HR-ESI-MS analysis. Compounds 2 and 3 exhibited strong cytotoxic activity against human central nervous system cancer (SF-268) with the IC50 values of 3.04 and 5.66 μg/ml, respectively. Moreover, compound 2 also displayed potent activity against human liver cancer (HepG2) with an IC50 value of 1.01 μg/ml.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Journal of Asian natural products research - 21(2019), 12 vom: 01. Dez., Seite 1151-1160 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Jian-Song [VerfasserIn] |
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| Links: |
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| Themen: |
Anthracenes |
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| Anmerkungen: |
Date Completed 21.02.2020 Date Revised 21.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10286020.2018.1520222 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292148542 |
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| 245 | 1 | 0 | |a Bioactive naphthoquinone and anthrone derivatives from endophytic Micromonospora sp. NEAU-gq13 |
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| 500 | |a Date Completed 21.02.2020 | ||
| 500 | |a Date Revised 21.02.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Two new naphthalenone derivatives, 5-hydroxy-4-oxo-2-(2-oxopropyl)-1,2,3,4-tetrahydronaphthalen-1-yl acetate (1) and 5-hydroxy-2-(2-hydroxypropyl)naphthalene-1,4-dione (2), together with two new anthrone derivatives, (S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3) and 4,5-dihydroxy-2-methyl-9H-xanthen-9-one (4), were isolated from the fermentation broth of endophytic Micromonospora sp. NEAU-gq13. Their structures were determined by 1D-NMR, 2D-NMR, and HR-ESI-MS analysis. Compounds 2 and 3 exhibited strong cytotoxic activity against human central nervous system cancer (SF-268) with the IC50 values of 3.04 and 5.66 μg/ml, respectively. Moreover, compound 2 also displayed potent activity against human liver cancer (HepG2) with an IC50 value of 1.01 μg/ml | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Endophytic micro-organisms | |
| 650 | 4 | |a Micromonospora sp. NEAU-gq13 | |
| 650 | 4 | |a cytotoxic activities | |
| 650 | 4 | |a naphthoquinone and anthrone derivatives | |
| 650 | 7 | |a Anthracenes |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Naphthoquinones |2 NLM | |
| 700 | 1 | |a Zhang, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Qi, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ji-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Xiang, Wen-Sheng |e verfasserin |4 aut | |
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