Acute kidney injury caused by the intraperitoneal injection of Bothrops jararaca venom in rats
We examined the ability of Bothrops jararaca venom (12.5 mg/kg) injected intraperitoneally (i.p.) to cause acute kidney injury (AKI) in rats. Blood urea and creatinine (AKI biomarkers, in g dL-1) were elevated after 2 h in venom-treated rats (urea: from 0.41 ± 0.1 to 0.7 ± 0.03; creatinine from 46.7 ± 3.1 to 85 ± 6.7; p < 0.05; n = 3 each), with no change in circulating reduced glutathione. Venom-treated rats survived for ∼6 h, at which point platelets were reduced (×103 µL-1; from 763.8 ± 30.2 to 52.5 ± 18.2) whereas leukocytes and erythrocytes were slightly increased (from 4.7 ± 0.3 to 6.6 ± 0.1 × 103 µL-1 and from 8.38 ± 0.1 to 9.2 ± 0.09 × 106 µL-1, respectively; p < 0.05); blood protein (5.2 ± 0.4 g dL-1) and albumin (2.7 ± 0.1 g dL-1) were normal, whereas blood and urinary urea and creatinine were increased. All parameters returned to normal with antivenom given 2 h post-envenomation. The i.p. injection of venom caused AKI similar to that seen with other routes of administration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Natural product research - 34(2020), 17 vom: 01. Sept., Seite 2533-2538 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yoshida, Edson Hideaki [VerfasserIn] |
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| Links: |
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| Themen: |
AYI8EX34EU |
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| Anmerkungen: |
Date Completed 18.09.2020 Date Revised 18.09.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14786419.2018.1543675 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM292100043 |
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| 100 | 1 | |a Yoshida, Edson Hideaki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Acute kidney injury caused by the intraperitoneal injection of Bothrops jararaca venom in rats |
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| 520 | |a We examined the ability of Bothrops jararaca venom (12.5 mg/kg) injected intraperitoneally (i.p.) to cause acute kidney injury (AKI) in rats. Blood urea and creatinine (AKI biomarkers, in g dL-1) were elevated after 2 h in venom-treated rats (urea: from 0.41 ± 0.1 to 0.7 ± 0.03; creatinine from 46.7 ± 3.1 to 85 ± 6.7; p < 0.05; n = 3 each), with no change in circulating reduced glutathione. Venom-treated rats survived for ∼6 h, at which point platelets were reduced (×103 µL-1; from 763.8 ± 30.2 to 52.5 ± 18.2) whereas leukocytes and erythrocytes were slightly increased (from 4.7 ± 0.3 to 6.6 ± 0.1 × 103 µL-1 and from 8.38 ± 0.1 to 9.2 ± 0.09 × 106 µL-1, respectively; p < 0.05); blood protein (5.2 ± 0.4 g dL-1) and albumin (2.7 ± 0.1 g dL-1) were normal, whereas blood and urinary urea and creatinine were increased. All parameters returned to normal with antivenom given 2 h post-envenomation. The i.p. injection of venom caused AKI similar to that seen with other routes of administration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute kidney injury | |
| 650 | 4 | |a Bothrops jararaca | |
| 650 | 4 | |a blood incoagulability | |
| 650 | 7 | |a Antivenins |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Crotalid Venoms |2 NLM | |
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| 700 | 1 | |a Dini, Murilo Melo Juste |e verfasserin |4 aut | |
| 700 | 1 | |a Campanholi, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Cogo, José Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Grotto, Denise |e verfasserin |4 aut | |
| 700 | 1 | |a Hyslop, Stephen |e verfasserin |4 aut | |
| 700 | 1 | |a Hanai-Yoshida, Valquíria Miwa |e verfasserin |4 aut | |
| 700 | 1 | |a Oshima-Franco, Yoko |e verfasserin |4 aut | |
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