The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients
Copyright © 2018 Elsevier Inc. All rights reserved..
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had a heterogeneous immune infiltrate and mutational diversity. Small metastases had frequently a low Immunoscore and T and B cell score, while a high Immunoscore was associated with a lower number of metastases. Anti-epidermal growth factor receptor treatment modified immune gene expression and significantly increased T cell densities in the metastasis core. The predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1). The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases.
| Errataetall: |
CommentIn: Cancer Cell. 2018 Dec 10;34(6):876-878. - PMID 30537510 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Cancer cell - 34(2018), 6 vom: 10. Dez., Seite 1012-1026.e3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Van den Eynde, Marc [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.07.2019 Date Revised 29.07.2019 published: Print CommentIn: Cancer Cell. 2018 Dec 10;34(6):876-878. - PMID 30537510 Citation Status MEDLINE |
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| doi: |
10.1016/j.ccell.2018.11.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2018 Elsevier Inc. All rights reserved. | ||
| 520 | |a Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had a heterogeneous immune infiltrate and mutational diversity. Small metastases had frequently a low Immunoscore and T and B cell score, while a high Immunoscore was associated with a lower number of metastases. Anti-epidermal growth factor receptor treatment modified immune gene expression and significantly increased T cell densities in the metastasis core. The predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1). The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases | ||
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