Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology
© 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd..
BACKGROUND: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure.
PATIENTS AND METHODS: Between 2006-2010, 84 patients with various types of sarcoma underwent surgery followed by three-dimensional histology. Tumor entities included dermatofibrosarcoma protuberans (DFSP, 54 patients), leiomyosarcoma (ten patients), rhabdomyosarcoma (one patient), angiosarcoma (seven patients) as well as atypical fibroxanthoma (AFX, three patients) and cutaneous undifferentiated pleomorphic sarcoma (UPS, nine patients). Median follow-up was four years (range: 2-6 years).
RESULTS: Local recurrence rates among patients with primary DFSP were 2.2 %. All patients undergoing re-excision were subsequently tumor free. Patients with leiomyosarcoma, rhabdomyosarcoma, AFX, and cutaneous UPS experienced no local recurrence; however, one individual developed in-transit metastasis (UPS) (8.3 %). Three patients with angiosarcoma developed local recurrence (43 %), two of whom remained tumor free following re-excision. Two angiosarcoma patients died from distant metastases (29 %). Both DFSP and especially angiosarcoma lesions exhibited extensive subclinical growth.
CONCLUSIONS: Recurrence rates of cutaneous sarcomas following three-dimensional histology are low. Local recurrences are readily manageable by re-excision. Angiosarcoma is characterized by extensive superficial growth, aggressive biological behavior, and predominantly hematogenous spread.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2018 |
---|---|
Erschienen: |
2018 |
Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
---|---|
Enthalten in: |
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG - 16(2018), 12 vom: 10. Dez., Seite 1434-1442 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Welsch, Katharina [VerfasserIn] |
---|
Links: |
---|
Themen: |
---|
Anmerkungen: |
Date Completed 26.08.2019 Date Revised 26.08.2019 published: Print Citation Status MEDLINE |
---|
doi: |
10.1111/ddg.13708 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM29167447X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM29167447X | ||
003 | DE-627 | ||
005 | 20231225071408.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2018 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1111/ddg.13708 |2 doi | |
028 | 5 | 2 | |a pubmed24n0972.xml |
035 | |a (DE-627)NLM29167447X | ||
035 | |a (NLM)30537312 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Welsch, Katharina |e verfasserin |4 aut | |
245 | 1 | 0 | |a Patterns of infiltration and local recurrences of various types of cutaneous sarcomas following three-dimensional histology |
264 | 1 | |c 2018 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 26.08.2019 | ||
500 | |a Date Revised 26.08.2019 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd. | ||
520 | |a BACKGROUND: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure | ||
520 | |a PATIENTS AND METHODS: Between 2006-2010, 84 patients with various types of sarcoma underwent surgery followed by three-dimensional histology. Tumor entities included dermatofibrosarcoma protuberans (DFSP, 54 patients), leiomyosarcoma (ten patients), rhabdomyosarcoma (one patient), angiosarcoma (seven patients) as well as atypical fibroxanthoma (AFX, three patients) and cutaneous undifferentiated pleomorphic sarcoma (UPS, nine patients). Median follow-up was four years (range: 2-6 years) | ||
520 | |a RESULTS: Local recurrence rates among patients with primary DFSP were 2.2 %. All patients undergoing re-excision were subsequently tumor free. Patients with leiomyosarcoma, rhabdomyosarcoma, AFX, and cutaneous UPS experienced no local recurrence; however, one individual developed in-transit metastasis (UPS) (8.3 %). Three patients with angiosarcoma developed local recurrence (43 %), two of whom remained tumor free following re-excision. Two angiosarcoma patients died from distant metastases (29 %). Both DFSP and especially angiosarcoma lesions exhibited extensive subclinical growth | ||
520 | |a CONCLUSIONS: Recurrence rates of cutaneous sarcomas following three-dimensional histology are low. Local recurrences are readily manageable by re-excision. Angiosarcoma is characterized by extensive superficial growth, aggressive biological behavior, and predominantly hematogenous spread | ||
650 | 4 | |a Journal Article | |
700 | 1 | |a Breuninger, Helmut |e verfasserin |4 aut | |
700 | 1 | |a Metzler, Gisela |e verfasserin |4 aut | |
700 | 1 | |a Sickinger, Franziska |e verfasserin |4 aut | |
700 | 1 | |a Eberle, Franziska Carola |e verfasserin |4 aut | |
700 | 1 | |a Häfner, Hans-Martin |e verfasserin |4 aut | |
700 | 1 | |a Schnabl, Saskia Maria |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG |d 2003 |g 16(2018), 12 vom: 10. Dez., Seite 1434-1442 |w (DE-627)NLM155366637 |x 1610-0387 |7 nnns |
773 | 1 | 8 | |g volume:16 |g year:2018 |g number:12 |g day:10 |g month:12 |g pages:1434-1442 |
856 | 4 | 0 | |u http://dx.doi.org/10.1111/ddg.13708 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 16 |j 2018 |e 12 |b 10 |c 12 |h 1434-1442 |