Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic : Waning and association with self-reported severity and duration of illness
© 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd..
BACKGROUND: A population-based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy.
OBJECTIVES: We studied maternal A(H1N1)pdm09-specific hemagglutination inhibition (HI)-titer levels and waning in women with influenza-like illness (ILI) in pregnancy compared to vaccinated women. Moreover, we studied the association between HI-titers and self-reported severity and duration of ILI.
METHODS: HI-titers against the pandemic virus were measured in maternal blood samples obtained at birth, 3-9 months after exposure, and linked with information about pregnancy, influenza and vaccination from national registries and a cohort questionnaire.
RESULTS: Among 1821 pregnant women included, 43.7% were unvaccinated and 19.3% of these had ILI. HI-titers were low (geometric mean titer (GMT) 11.3) in the unvaccinated women with ILI. Higher HI-titers (GMT 37.8) were measured in the vaccinated women. Estimated HI-titer waning was similar for vaccinated women and women with ILI. Most ILI episodes were moderate and lasted 3-5 days. Women with ILI reporting specific influenza symptoms such as fever or cough had higher HI-titers than women without these symptoms. Women who reported being "very ill" or illness duration of >5 days had higher HI-titers than women reporting less severe illness or illness of shorter duration, respectively.
CONCLUSIONS: Antibody waning was similar in vaccinated women and women with ILI. More severe ILI or longer duration of illness was associated with higher HI-titers. Most unvaccinated pregnant women with ILI had low HI-titers, probably due to moderate illness and HI-titer waning between exposure and sampling.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Influenza and other respiratory viruses - 13(2019), 2 vom: 01. März, Seite 191-200 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tunheim, Gro [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies |
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| Anmerkungen: |
Date Completed 29.11.2019 Date Revised 09.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/irv.12623 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM291667457 |
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| 245 | 1 | 0 | |a Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic |b Waning and association with self-reported severity and duration of illness |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 29.11.2019 | ||
| 500 | |a Date Revised 09.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. | ||
| 520 | |a BACKGROUND: A population-based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy | ||
| 520 | |a OBJECTIVES: We studied maternal A(H1N1)pdm09-specific hemagglutination inhibition (HI)-titer levels and waning in women with influenza-like illness (ILI) in pregnancy compared to vaccinated women. Moreover, we studied the association between HI-titers and self-reported severity and duration of ILI | ||
| 520 | |a METHODS: HI-titers against the pandemic virus were measured in maternal blood samples obtained at birth, 3-9 months after exposure, and linked with information about pregnancy, influenza and vaccination from national registries and a cohort questionnaire | ||
| 520 | |a RESULTS: Among 1821 pregnant women included, 43.7% were unvaccinated and 19.3% of these had ILI. HI-titers were low (geometric mean titer (GMT) 11.3) in the unvaccinated women with ILI. Higher HI-titers (GMT 37.8) were measured in the vaccinated women. Estimated HI-titer waning was similar for vaccinated women and women with ILI. Most ILI episodes were moderate and lasted 3-5 days. Women with ILI reporting specific influenza symptoms such as fever or cough had higher HI-titers than women without these symptoms. Women who reported being "very ill" or illness duration of >5 days had higher HI-titers than women reporting less severe illness or illness of shorter duration, respectively | ||
| 520 | |a CONCLUSIONS: Antibody waning was similar in vaccinated women and women with ILI. More severe ILI or longer duration of illness was associated with higher HI-titers. Most unvaccinated pregnant women with ILI had low HI-titers, probably due to moderate illness and HI-titer waning between exposure and sampling | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a antibodies | |
| 650 | 4 | |a influenza | |
| 650 | 4 | |a pandemic H1N1pdm09 | |
| 650 | 4 | |a pregnancy | |
| 650 | 4 | |a vaccination | |
| 650 | 4 | |a waning | |
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| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Laake, Ida |e verfasserin |4 aut | |
| 700 | 1 | |a Robertson, Anna Hayman |e verfasserin |4 aut | |
| 700 | 1 | |a Waalen, Kristian |e verfasserin |4 aut | |
| 700 | 1 | |a Hungnes, Olav |e verfasserin |4 aut | |
| 700 | 1 | |a Naess, Lisbeth M |e verfasserin |4 aut | |
| 700 | 1 | |a Cox, Rebecca J |e verfasserin |4 aut | |
| 700 | 1 | |a Mjaaland, Siri |e verfasserin |4 aut | |
| 700 | 1 | |a Trogstad, Lill |e verfasserin |4 aut | |
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