With great power comes great vulnerability

The clinical responses to targeted drugs are often transient and do not always translate into meaningful overall survival due to the development of resistance. We discuss here that the greater power of drug resistant cells can be associated with significant newly-acquired vulnerabilities that can be exploited therapeutically.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:5

Enthalten in:

Molecular & cellular oncology - 5(2018), 6 vom: 29., Seite e1509488

Sprache:

Englisch

Beteiligte Personen:

Leite de Oliveira, Rodrigo [VerfasserIn]
Wang, Liqin [VerfasserIn]
Bernards, Rene [VerfasserIn]

Links:

Volltext

Themen:

BRAF
Drug resistance
Histone deacetylase inhibitor
Journal Article
Melanoma
Reactive oxygen species

Anmerkungen:

Date Revised 01.10.2020

published: Electronic-eCollection

Citation Status PubMed-not-MEDLINE

doi:

10.1080/23723556.2018.1509488

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM291554016