Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility
BACKGROUND: Preeclampsia (PE) is one of the main causes of death among the pregnant women as well as newborns. Although the etiological cause of preeclampsia is not yet clear, a range of risk factors has been suggested. MicroRNAs (like miRNA-152) are small non-coding molecules that play a role in a wide spectrum of biological processes, such as cell proliferation and angiogenesis. This study aimed to investigate the possible relationship of miRNA-152 rs12940701 polymorphism and the risk of preeclampsia among the pregnant women as compared with the control group.
METHODS: Genotyping of miRNA-152 rs12940701 polymorphism was performed using blood and placenta samples of 223 preeclampsia women and 229 normotensive pregnant women by a polymerase chain reaction-restriction fragment length polymorphism method.
RESULTS: The results obtained from maternal blood showed an increase in T alleles for PE women, that there was no significant difference between the PE and control group (OR = 1.7, P = 0.19). In addition, no significant difference was found in the TT genotype between the two groups (11.6% vs. 7%, OR = 1.4, P = 0.3). Similarly, the results obtained from placental samples were identical.
CONCLUSIONS: A lack of relationship between the polymorphism of miRNA-152 rs12940701 gene and preeclampsia development has been shown.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:299 |
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| Enthalten in: |
Archives of gynecology and obstetrics - 299(2019), 2 vom: 26. Feb., Seite 475-480 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rokni, Mohsen [VerfasserIn] |
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| Links: |
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| Themen: |
Gene |
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| Anmerkungen: |
Date Completed 07.02.2020 Date Revised 07.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00404-018-4979-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM291099467 |
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| 245 | 1 | 0 | |a Association between miRNA-152 polymorphism and risk of preeclampsia susceptibility |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 07.02.2020 | ||
| 500 | |a Date Revised 07.02.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Preeclampsia (PE) is one of the main causes of death among the pregnant women as well as newborns. Although the etiological cause of preeclampsia is not yet clear, a range of risk factors has been suggested. MicroRNAs (like miRNA-152) are small non-coding molecules that play a role in a wide spectrum of biological processes, such as cell proliferation and angiogenesis. This study aimed to investigate the possible relationship of miRNA-152 rs12940701 polymorphism and the risk of preeclampsia among the pregnant women as compared with the control group | ||
| 520 | |a METHODS: Genotyping of miRNA-152 rs12940701 polymorphism was performed using blood and placenta samples of 223 preeclampsia women and 229 normotensive pregnant women by a polymerase chain reaction-restriction fragment length polymorphism method | ||
| 520 | |a RESULTS: The results obtained from maternal blood showed an increase in T alleles for PE women, that there was no significant difference between the PE and control group (OR = 1.7, P = 0.19). In addition, no significant difference was found in the TT genotype between the two groups (11.6% vs. 7%, OR = 1.4, P = 0.3). Similarly, the results obtained from placental samples were identical | ||
| 520 | |a CONCLUSIONS: A lack of relationship between the polymorphism of miRNA-152 rs12940701 gene and preeclampsia development has been shown | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Gene | |
| 650 | 4 | |a Polymorphism | |
| 650 | 4 | |a Preeclampsia | |
| 650 | 4 | |a miRNA-152 | |
| 650 | 7 | |a MIRN152 microRNA, human |2 NLM | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
| 700 | 1 | |a Salimi, Saeedeh |e verfasserin |4 aut | |
| 700 | 1 | |a Sohrabi, Tayebeh |e verfasserin |4 aut | |
| 700 | 1 | |a Asghari, Somaye |e verfasserin |4 aut | |
| 700 | 1 | |a Teimoori, Batool |e verfasserin |4 aut | |
| 700 | 1 | |a Saravani, Mohsen |e verfasserin |4 aut | |
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