Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations : Results of a Multicenter International Study
OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.
METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.
RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.
CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
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| Enthalten in: |
The Journal of rheumatology - 46(2019), 3 vom: 12. März, Seite 279-284 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 26.06.2020 Date Revised 26.06.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.3899/jrheum.180355 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM290749875 |
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| 100 | 1 | |a Sebastiani, Marco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Nailfold Capillaroscopy Characteristics of Antisynthetase Syndrome and Possible Clinical Associations |b Results of a Multicenter International Study |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.06.2020 | ||
| 500 | |a Date Revised 26.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease | ||
| 520 | |a METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody-negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures | ||
| 520 | |a RESULTS: NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP | ||
| 520 | |a CONCLUSION: NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a ANTISYNTHETASE ANTIBODIES | |
| 650 | 4 | |a ANTISYNTHETASE SYNDROME | |
| 650 | 4 | |a NAILFOLD VIDEOCAPILLAROSCOPY | |
| 650 | 4 | |a RAYNAUD PHENOMENON | |
| 650 | 4 | |a SYSTEMIC SCLEROSIS PATTERN | |
| 650 | 7 | |a Antibodies, Antinuclear |2 NLM | |
| 650 | 7 | |a Jo-1 antibody |2 NLM | |
| 650 | 7 | |a Amino Acyl-tRNA Synthetases |2 NLM | |
| 650 | 7 | |a EC 6.1.1.- |2 NLM | |
| 700 | 1 | |a Triantafyllias, Konstantinos |e verfasserin |4 aut | |
| 700 | 1 | |a Manfredi, Andreina |e verfasserin |4 aut | |
| 700 | 1 | |a González-Gay, Miguel Angel |e verfasserin |4 aut | |
| 700 | 1 | |a Palmou-Fontana, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Cassone, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Drott, Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Delbrück, Christiane |e verfasserin |4 aut | |
| 700 | 1 | |a Rojas-Serrano, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Bertolazzi, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Nuño, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Giannini, Margherita |e verfasserin |4 aut | |
| 700 | 1 | |a Iannone, Florenzo |e verfasserin |4 aut | |
| 700 | 1 | |a Vicente, Esther F |e verfasserin |4 aut | |
| 700 | 1 | |a Castañeda, Santos |e verfasserin |4 aut | |
| 700 | 1 | |a Selva-O'Callaghan, Albert |e verfasserin |4 aut | |
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| 700 | 1 | |a Montecucco, Carlomaurizio |e verfasserin |4 aut | |
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| 700 | 1 | |a Nieto-González, Juan Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Vichi, Silvia |e verfasserin |4 aut | |
| 700 | 1 | |a Confalonieri, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Tomietto, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Bergner, Raoul |e verfasserin |4 aut | |
| 700 | 1 | |a Sulli, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Bonella, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Furini, Federica |e verfasserin |4 aut | |
| 700 | 1 | |a Scirè, Carlo Alberto |e verfasserin |4 aut | |
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| 700 | 1 | |a Specker, Christof |e verfasserin |4 aut | |
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| 700 | 0 | |a American and European Network of Antisynthetase Syndrome Collaborative Group |e verfasserin |4 aut | |
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