Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn's Disease and Ulcerative Colitis
Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial success in providing criteria for the differential diagnosis between ulcerative colitis (UC) and Crohn's disease (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers for improving classification and diagnosis of IBD. The aim of our study was to identify gene expression profiles specific for UC and CD, in endoscopically affected and normal intestinal colonic mucosa from IBD patients. We evaluated a panel of 84 genes related to the IBD-inflammatory pathway on 21 UC and 22 CD paired inflamed and not inflamed mucosa and on age-matched normal mucosa from 21 non-IBD controls. Two genes in UC (CCL11 and MMP10) and two in CD (C4BPB and IL1RN) showed an upregulation trend in both noninflamed and inflamed mucosa compared to controls. Our results suggest that the transcript levels of CCL11, MMP10, C4BPB, and IL1RN are candidate biomarkers that could help in clinical practice for the differential diagnosis between UC and CD and could guide new research on future therapeutic targets.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2018 |
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| Enthalten in: |
Journal of immunology research - 2018(2018) vom: 27., Seite 9208274 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dobre, Maria [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 11.01.2019 Date Revised 11.01.2019 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1155/2018/9208274 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM290496756 |
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| 100 | 1 | |a Dobre, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Differential Intestinal Mucosa Transcriptomic Biomarkers for Crohn's Disease and Ulcerative Colitis |
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| 500 | |a Date Completed 11.01.2019 | ||
| 500 | |a Date Revised 11.01.2019 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial success in providing criteria for the differential diagnosis between ulcerative colitis (UC) and Crohn's disease (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers for improving classification and diagnosis of IBD. The aim of our study was to identify gene expression profiles specific for UC and CD, in endoscopically affected and normal intestinal colonic mucosa from IBD patients. We evaluated a panel of 84 genes related to the IBD-inflammatory pathway on 21 UC and 22 CD paired inflamed and not inflamed mucosa and on age-matched normal mucosa from 21 non-IBD controls. Two genes in UC (CCL11 and MMP10) and two in CD (C4BPB and IL1RN) showed an upregulation trend in both noninflamed and inflamed mucosa compared to controls. Our results suggest that the transcript levels of CCL11, MMP10, C4BPB, and IL1RN are candidate biomarkers that could help in clinical practice for the differential diagnosis between UC and CD and could guide new research on future therapeutic targets | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a C4BPB protein, human |2 NLM | |
| 650 | 7 | |a CCL11 protein, human |2 NLM | |
| 650 | 7 | |a Chemokine CCL11 |2 NLM | |
| 650 | 7 | |a Histocompatibility Antigens |2 NLM | |
| 650 | 7 | |a IL1RN protein, human |2 NLM | |
| 650 | 7 | |a Interleukin 1 Receptor Antagonist Protein |2 NLM | |
| 650 | 7 | |a MMP10 protein, human |2 NLM | |
| 650 | 7 | |a EC 3.4.24.22 |2 NLM | |
| 650 | 7 | |a Matrix Metalloproteinase 10 |2 NLM | |
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| 700 | 1 | |a Milanesi, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Mănuc, Teodora Ecaterina |e verfasserin |4 aut | |
| 700 | 1 | |a Arsene, Dorel Eugen |e verfasserin |4 aut | |
| 700 | 1 | |a Ţieranu, Cristian George |e verfasserin |4 aut | |
| 700 | 1 | |a Maj, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Becheanu, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Mănuc, Mircea |e verfasserin |4 aut | |
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