Circulating renin-angiotensin system-regulating specific aminopeptidase activities in pre- and post- menopausal women with breast cancer treated or not with neoadyuvant chemotherapy. A two years follow up study
Copyright © 2018 Elsevier Ltd. All rights reserved..
We have previously described changes in several circulating renin-angiotensin system (RAS)-regulating aminopeptidase activities in pre- and postmenopausal women with breast cancer treated or not with neoadjuvant chemotherapy. Women with breast cancer presented a reduced catabolism of angiotensin II (AngII) when compared to healthy individuals, although specific enzyme activities were different between pre- and post- menopausal women. In addition, neoadjuvant chemotherapy in breast cancer patients caused changes in aminopeptidase activities leading to increased AngII catabolism independently of hormonal status. Here we extend the aminopeptidase analysis to three time points of the patient follow-up (6, 12, and 24 months). No changes occur in enzyme activities during this time period and the effects of therapy remain unaltered overtime both in pre- and in postmenopausal women.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Breast (Edinburgh, Scotland) - 43(2019) vom: 15. Feb., Seite 28-30 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ramírez-Exposito, María Jesús [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.05.2019 Date Revised 28.05.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.breast.2018.10.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM290414725 |
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| 520 | |a We have previously described changes in several circulating renin-angiotensin system (RAS)-regulating aminopeptidase activities in pre- and postmenopausal women with breast cancer treated or not with neoadjuvant chemotherapy. Women with breast cancer presented a reduced catabolism of angiotensin II (AngII) when compared to healthy individuals, although specific enzyme activities were different between pre- and post- menopausal women. In addition, neoadjuvant chemotherapy in breast cancer patients caused changes in aminopeptidase activities leading to increased AngII catabolism independently of hormonal status. Here we extend the aminopeptidase analysis to three time points of the patient follow-up (6, 12, and 24 months). No changes occur in enzyme activities during this time period and the effects of therapy remain unaltered overtime both in pre- and in postmenopausal women | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Menopause | |
| 650 | 4 | |a Neoadjuvant | |
| 650 | 4 | |a Renin-angiotensin system | |
| 650 | 7 | |a Anthracyclines |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents, Hormonal |2 NLM | |
| 650 | 7 | |a Antineoplastic Agents, Immunological |2 NLM | |
| 650 | 7 | |a Aromatase Inhibitors |2 NLM | |
| 650 | 7 | |a Tamoxifen |2 NLM | |
| 650 | 7 | |a 094ZI81Y45 |2 NLM | |
| 650 | 7 | |a Angiotensin II |2 NLM | |
| 650 | 7 | |a 11128-99-7 |2 NLM | |
| 650 | 7 | |a Aminopeptidases |2 NLM | |
| 650 | 7 | |a EC 3.4.11.- |2 NLM | |
| 650 | 7 | |a CD13 Antigens |2 NLM | |
| 650 | 7 | |a EC 3.4.11.2 |2 NLM | |
| 650 | 7 | |a aminopeptidase B |2 NLM | |
| 650 | 7 | |a EC 3.4.11.6 |2 NLM | |
| 650 | 7 | |a Glutamyl Aminopeptidase |2 NLM | |
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| 650 | 7 | |a Paclitaxel |2 NLM | |
| 650 | 7 | |a P88XT4IS4D |2 NLM | |
| 700 | 1 | |a Dueñas-Rodríguez, Basilio |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-Martos, José Manuel |e verfasserin |4 aut | |
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