WNK pathways in cancer signaling networks
BACKGROUND: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters.
MAIN BODY: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes.
CONCLUSION: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Cell communication and signaling : CCS - 16(2018), 1 vom: 03. Nov., Seite 72 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gallolu Kankanamalage, Sachith [VerfasserIn] |
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| Links: |
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| Themen: |
And NF-κB |
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| Anmerkungen: |
Date Completed 15.05.2019 Date Revised 04.12.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12964-018-0287-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM290239796 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and a multitude of OSR1/SPAK substrates including cation chloride cotransporters | ||
| 520 | |a MAIN BODY: While the best known functions of the WNK pathway is regulation of ion transport across cell membranes, WNK pathway components have been implicated in numerous human diseases. The goal of our review is to draw attention to how this pathway and its components exert influence on the progression of cancer, specifically by detailing WNK signaling intersections with major cell communication networks and processes | ||
| 520 | |a CONCLUSION: Here we describe how WNKs and associated proteins interact with and influence PI3K-AKT, TGF-β, and NF-κB signaling, as well as its unanticipated role in the regulation of angiogenesis | ||
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| 650 | 4 | |a Review | |
| 650 | 4 | |a And NF-κB | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Cellular signaling | |
| 650 | 4 | |a Ion transport | |
| 650 | 4 | |a OSR1 | |
| 650 | 4 | |a PI3K-AKT | |
| 650 | 4 | |a SPAK | |
| 650 | 4 | |a STK39 | |
| 650 | 4 | |a TGF-β | |
| 650 | 4 | |a WNKs | |
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| 700 | 1 | |a Karra, Aroon S |e verfasserin |4 aut | |
| 700 | 1 | |a Cobb, Melanie H |e verfasserin |4 aut | |
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