Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors : One-Year Results of the PREDIMED-Plus Trial
© 2018 by the American Diabetes Association..
OBJECTIVE: The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention.
RESEARCH DESIGN AND METHODS: Overweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively.
RESULTS: Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P < 0.001), a mean difference of -2.5 kg (95% CI -3.1 to -1.9). Weight loss ≥5% occurred in 33.7% of IG participants compared with 11.9% in the CG (P < 0.001). Compared with the CG, cardiovascular risk factors, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol, significantly improved in IG participants (P < 0.002). Reductions in insulin resistance, HbA1c, and circulating levels of leptin, interleukin-18, and MCP-1 were greater in IG than CG participants (P < 0.05). IG participants with prediabetes/diabetes significantly improved glycemic control and insulin sensitivity, along with triglycerides and HDL cholesterol levels compared with their CG counterparts.
CONCLUSIONS: PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Diabetes care - 42(2019), 5 vom: 15. Mai, Seite 777-788 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Blood Glucose |
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| Anmerkungen: |
Date Completed 21.01.2020 Date Revised 31.03.2022 published: Print-Electronic ISRCTN: ISRCTN89898870 Citation Status MEDLINE |
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| doi: |
10.2337/dc18-0836 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Salas-Salvadó, Jordi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of a Lifestyle Intervention Program With Energy-Restricted Mediterranean Diet and Exercise on Weight Loss and Cardiovascular Risk Factors |b One-Year Results of the PREDIMED-Plus Trial |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 21.01.2020 | ||
| 500 | |a Date Revised 31.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ISRCTN: ISRCTN89898870 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 by the American Diabetes Association. | ||
| 520 | |a OBJECTIVE: The long-term impact of intentional weight loss on cardiovascular events remains unknown. We describe 12-month changes in body weight and cardiovascular risk factors in PREvención con DIeta MEDiterránea (PREDIMED)-Plus, a trial designed to evaluate the long-term effectiveness of an intensive weight loss lifestyle intervention on primary cardiovascular prevention | ||
| 520 | |a RESEARCH DESIGN AND METHODS: Overweight/obese adults with metabolic syndrome aged 55-75 years (n = 626) were randomized to an intensive weight loss lifestyle intervention based on an energy-restricted Mediterranean diet, physical activity promotion, and behavioral support (IG) or a control group (CG). The primary and secondary outcomes were changes in weight and cardiovascular risk markers, respectively | ||
| 520 | |a RESULTS: Diet and physical activity changes were in the expected direction, with significant improvements in IG versus CG. After 12 months, IG participants lost an average of 3.2 kg vs. 0.7 kg in the CG (P < 0.001), a mean difference of -2.5 kg (95% CI -3.1 to -1.9). Weight loss ≥5% occurred in 33.7% of IG participants compared with 11.9% in the CG (P < 0.001). Compared with the CG, cardiovascular risk factors, including waist circumference, fasting glucose, triglycerides, and HDL cholesterol, significantly improved in IG participants (P < 0.002). Reductions in insulin resistance, HbA1c, and circulating levels of leptin, interleukin-18, and MCP-1 were greater in IG than CG participants (P < 0.05). IG participants with prediabetes/diabetes significantly improved glycemic control and insulin sensitivity, along with triglycerides and HDL cholesterol levels compared with their CG counterparts | ||
| 520 | |a CONCLUSIONS: PREDIMED-Plus intensive lifestyle intervention for 12 months was effective in decreasing adiposity and improving cardiovascular risk factors in overweight/obese older adults with metabolic syndrome, as well as in individuals with or at risk for diabetes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
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| 700 | 1 | |a Ruiz-Canela, Miguel |e verfasserin |4 aut | |
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| 700 | 1 | |a Fitó, Montse |e verfasserin |4 aut | |
| 700 | 1 | |a Corella, Dolores |e verfasserin |4 aut | |
| 700 | 1 | |a Serra-Majem, Luís |e verfasserin |4 aut | |
| 700 | 1 | |a Wärnberg, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Romaguera, Dora |e verfasserin |4 aut | |
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| 700 | 1 | |a Vidal, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez, J Alfredo |e verfasserin |4 aut | |
| 700 | 1 | |a Arós, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Vázquez, Clotilde |e verfasserin |4 aut | |
| 700 | 1 | |a Ros, Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Vioque, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a López-Miranda, José |e verfasserin |4 aut | |
| 700 | 1 | |a Bueno-Cavanillas, Aurora |e verfasserin |4 aut | |
| 700 | 1 | |a Tur, Josep A |e verfasserin |4 aut | |
| 700 | 1 | |a Tinahones, Francisco J |e verfasserin |4 aut | |
| 700 | 1 | |a Martín, Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Lapetra, José |e verfasserin |4 aut | |
| 700 | 1 | |a Pintó, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Daimiel, Lidia |e verfasserin |4 aut | |
| 700 | 1 | |a Delgado-Rodríguez, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Matía, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez-Gracia, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Díez-Espino, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Babio, Nancy |e verfasserin |4 aut | |
| 700 | 1 | |a Castañer, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Sorlí, José V |e verfasserin |4 aut | |
| 700 | 1 | |a Fiol, Miquel |e verfasserin |4 aut | |
| 700 | 1 | |a Zulet, María Ángeles |e verfasserin |4 aut | |
| 700 | 1 | |a Bulló, Mònica |e verfasserin |4 aut | |
| 700 | 1 | |a Goday, Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Martínez-González, Miguel Á |e verfasserin |4 aut | |
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| 700 | 1 | |a Marcos, Ascensión |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Aranda, Fernando |e investigator |4 oth | |
| 700 | 1 | |a Botella, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Aldamiz, Mikel |e investigator |4 oth | |
| 700 | 1 | |a Alonso, Angel |e investigator |4 oth | |
| 700 | 1 | |a Berjón, Jesús |e investigator |4 oth | |
| 700 | 1 | |a Forga, Luis |e investigator |4 oth | |
| 700 | 1 | |a Gállego, Jaime |e investigator |4 oth | |
| 700 | 1 | |a García Layana, Alfredo |e investigator |4 oth | |
| 700 | 1 | |a Larrauri, Arantxa |e investigator |4 oth | |
| 700 | 1 | |a Portu, Joseba |e investigator |4 oth | |
| 700 | 1 | |a Timiraos, Juan |e investigator |4 oth | |
| 700 | 1 | |a Serrano-Martínez, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Toledo, Estefanía |e investigator |4 oth | |
| 700 | 1 | |a Buil-Cosiales, Pilar |e investigator |4 oth | |
| 700 | 1 | |a Razquin, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Bes-Rastrollo, Maira |e investigator |4 oth | |
| 700 | 1 | |a Sanchez Tainta, Ana |e investigator |4 oth | |
| 700 | 1 | |a SanJulian Aranguren, Beatriz |e investigator |4 oth | |
| 700 | 1 | |a Goñi, Estibaliz |e investigator |4 oth | |
| 700 | 1 | |a Barrientos, Irene |e investigator |4 oth | |
| 700 | 1 | |a Canales, Maria |e investigator |4 oth | |
| 700 | 1 | |a Rico, Anais |e investigator |4 oth | |
| 700 | 1 | |a Basterra Gortari, Javiar |e investigator |4 oth | |
| 700 | 1 | |a Garcia Arellano, Ana |e investigator |4 oth | |
| 700 | 1 | |a Lecea-Juarez, Oscar |e investigator |4 oth | |
| 700 | 1 | |a Carlos Cenoz-Osinaga, Juan |e investigator |4 oth | |
| 700 | 1 | |a Bartolome-Resano, Javier |e investigator |4 oth | |
| 700 | 1 | |a Sola-Larraza, Ana |e investigator |4 oth | |
| 700 | 1 | |a Lozano-Oloriz, Elisa |e investigator |4 oth | |
| 700 | 1 | |a Cano-Valles, Begoña |e investigator |4 oth | |
| 700 | 1 | |a Eguaras, Sonia |e investigator |4 oth | |
| 700 | 1 | |a Pascual Roquet-Jalmar, Elena |e investigator |4 oth | |
| 700 | 1 | |a Galilea-Zabalza, Iñigo |e investigator |4 oth | |
| 700 | 1 | |a Lancova, Hana |e investigator |4 oth | |
| 700 | 1 | |a Ramallal, Raul |e investigator |4 oth | |
| 700 | 1 | |a Garcia-Perez, Mª Luisa |e investigator |4 oth | |
| 700 | 1 | |a Estremera-Urabayen, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Ariz-Arnedo, Mª Jose |e investigator |4 oth | |
| 700 | 1 | |a Hijos-Larraz, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Fernandez Alfaro, Cristina |e investigator |4 oth | |
| 700 | 1 | |a Iñigo-Martinez, Begoña |e investigator |4 oth | |
| 700 | 1 | |a Villanueva Moreno, Ramón |e investigator |4 oth | |
| 700 | 1 | |a Martin-Almendros, Sonia |e investigator |4 oth | |
| 700 | 1 | |a Barandiaran-Bengoetxea, Luisa |e investigator |4 oth | |
| 700 | 1 | |a Fuertes-Goñi, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Lezaun-Indurain, Ana |e investigator |4 oth | |
| 700 | 1 | |a Guruchaga-Arcelus, Mª Jose |e investigator |4 oth | |
| 700 | 1 | |a Olmedo-Cruz, Oscar |e investigator |4 oth | |
| 700 | 1 | |a Iñigo-Martínez, Begoña |e investigator |4 oth | |
| 700 | 1 | |a Escriche-Erviti, Luis |e investigator |4 oth | |
| 700 | 1 | |a Ansorena-Ros, Roberto |e investigator |4 oth | |
| 700 | 1 | |a Sanmatin Zabaleta, Rosario |e investigator |4 oth | |
| 700 | 1 | |a Apalategi-Lasa, Jon |e investigator |4 oth | |
| 700 | 1 | |a Villanueva-Telleria, Jerusalen |e investigator |4 oth | |
| 700 | 1 | |a Hernández-Espinosa, Mª Mar |e investigator |4 oth | |
| 700 | 1 | |a Arroyo-Bergera, Isabel |e investigator |4 oth | |
| 700 | 1 | |a Herrera-Valdez, Lissy |e investigator |4 oth | |
| 700 | 1 | |a Dorronsoro-Dorronsoro, Lourdes |e investigator |4 oth | |
| 700 | 1 | |a Ignacio González, José |e investigator |4 oth | |
| 700 | 1 | |a Portolés, Olga |e investigator |4 oth | |
| 700 | 1 | |a Fernández-Carrión, Rebeca |e investigator |4 oth | |
| 700 | 1 | |a Ortega-Azorín, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Barragán, Rocío |e investigator |4 oth | |
| 700 | 1 | |a María Asensio, Eva |e investigator |4 oth | |
| 700 | 1 | |a Coltell, Oscar |e investigator |4 oth | |
| 700 | 1 | |a Sáiz, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Osma, Rosana |e investigator |4 oth | |
| 700 | 1 | |a Férriz, Esther |e investigator |4 oth | |
| 700 | 1 | |a González-Monje, Inmaculada |e investigator |4 oth | |
| 700 | 1 | |a Giménez-Fernández, Francisco |e investigator |4 oth | |
| 700 | 1 | |a Quiles, Laura |e investigator |4 oth | |
| 700 | 1 | |a Carrasco, Paula |e investigator |4 oth | |
| 700 | 1 | |a San Onofre, Nadia |e investigator |4 oth | |
| 700 | 1 | |a Carratalá-Calvo, Arturo |e investigator |4 oth | |
| 700 | 1 | |a Valero-Barceló, Carmen |e investigator |4 oth | |
| 700 | 1 | |a Antón, Francisco |e investigator |4 oth | |
| 700 | 1 | |a Mir, Carolina |e investigator |4 oth | |
| 700 | 1 | |a Sánchez-Navarro, Silvia |e investigator |4 oth | |
| 700 | 1 | |a Navas, Jesús |e investigator |4 oth | |
| 700 | 1 | |a González-Gallego, Inmaculada |e investigator |4 oth | |
| 700 | 1 | |a Bort-Llorca, Laia |e investigator |4 oth | |
| 700 | 1 | |a Pérez-Ollero, Laura |e investigator |4 oth | |
| 700 | 1 | |a Giner-Valero, Mercedes |e investigator |4 oth | |
| 700 | 1 | |a Monfort-Sáez, Rogelio |e investigator |4 oth | |
| 700 | 1 | |a José Nadal-Sayol, Juan |e investigator |4 oth | |
| 700 | 1 | |a Pascual-Fuster, Vicente |e investigator |4 oth | |
| 700 | 1 | |a Martínez-Pérez, Magdalena |e investigator |4 oth | |
| 700 | 1 | |a Riera, Concha |e investigator |4 oth | |
| 700 | 1 | |a Vicenta Belda, María |e investigator |4 oth | |
| 700 | 1 | |a Medina, Amparo |e investigator |4 oth | |
| 700 | 1 | |a Miralles, Enrique |e investigator |4 oth | |
| 700 | 1 | |a José Ramírez-Esplugues, María |e investigator |4 oth | |
| 700 | 1 | |a Rojo-Furió, Manuel |e investigator |4 oth | |
| 700 | 1 | |a Mattingley, George |e investigator |4 oth | |
| 700 | 1 | |a Ángeles Delgado, María |e investigator |4 oth | |
| 700 | 1 | |a Ángeles Pages, María |e investigator |4 oth | |
| 700 | 1 | |a Riofrío, Yolanda |e investigator |4 oth | |
| 700 | 1 | |a Abuomar, Lubna |e investigator |4 oth | |
| 700 | 1 | |a Blasco-Lafarga, Nieves |e investigator |4 oth | |
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