Effects of Moringa oleifera on Insulin Levels and Folliculogenesis in Polycystic Ovary Syndrome Model with Insulin Resistance

BACKGROUND: Insulin resistance is a frequent metabolic disorder in Polycystic Ovary Syndrome (PCOS). Moringa oleifera has been shown to increase insulin expres-sion and decrease the degree of insulin in diabetes mellitus, therefore it is expected that Moringa oleifera could decrease insulin levels and increase folliculogenesis in PCOS.

OBJECTIVE: To prove the effect of Moringa oleifera leaf extract in various doses might decrease the insulin levels and increase folliculogenesis in female PCOS-insulin resistant rats.

METHODS: The three month old white rat of Wistar strain (Rattus norvegicus) 100-130 grams were divided into five groups (n=8) including normal control, PCOS-insulin re-sistance, PCOS-insulin resistance given metformin and PCOS-resistance insulin were giv-en Moringa oleifera leaf extract in two doses. Then, the PCOS model-insulin resistance by injection of testosterone propionate for 28 days. After 14 days treatment, we analysed insulin levels and folliculogenesis.

RESULTS: The PCOS control group showed a significant increase in insulin levels compared to the normal control group. The insulin levels from group treatment with Moringa oleifera leaf extract of 250 mg/kgBW was significantly lower than the PCOS control group. Ovarian histology analysis found that the number and diameter of follicle of PCOS control group showed a significant decrease compared to normal control group. In addition, the treatment with metformin and leaf Moringa oleifera dose 250 mg/kgBW and 500 mg/kgBW showed significant increase of folliculogenesis compared to PCOS control group.

CONCLUSIONS: Moringa oleifera could lowering the blood insulin levels, subsequently decreasing the androgen thus allowed the increasing of folliculogenesis in PCOS.

Media Type:

Electronic Article

Year of Publication:

2018

Publication:

2018

Contained In:

To Main Record - volume:18

Contained In:

Immunology, endocrine & metabolic agents in medicinal chemistry - 18(2018), 1 vom: 29. Mai, Seite 22-30

Language:

English

Contributors:

Amelia, Dessy [Author]
Santoso, Budi [Author]
Purwanto, Bambang [Author]
Miftahussurur, Muhammad [Author]
Joewono, Hermanto Tri [Author]
Budiono [Author]

Links:

Volltext

Keywords:

Diabetes
Folliculogenesis
Insulin
Journal Article
Moringa oleifera
Polycystic ovary syndrome
Testosterone

Notes:

Date Revised 21.03.2022

published: Print

Citation Status PubMed-not-MEDLINE

doi:

10.2174/1871522218666180426100754

funding:

Supporting institution / Project title:

PPN (Catalogue-ID):

NLM290039479