Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides
In this paper we present the first example of a lysosome-targeting fluorescent ionophore. Specifically, we synthesized a squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found that it was able to target and efficiently deacidify lysosomes. In contrast, an analogue without a morpholinyl group exhibits much lower ability to localize in lysosomes and is much less active in regulating the lysosomal pH.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Organic & biomolecular chemistry - 16(2018), 43 vom: 07. Nov., Seite 8025-8029 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hong, Xiao-Qiao [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 04.03.2019 Date Revised 04.03.2019 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/c8ob01957f |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM289686822 |
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| 245 | 1 | 0 | |a Synthesis and properties of a lysosome-targeting fluorescent ionophore based on coumarins and squaramides |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a In this paper we present the first example of a lysosome-targeting fluorescent ionophore. Specifically, we synthesized a squaramide derivative bearing a coumarin fluorophore and a morpholinyl group, and found that it was able to target and efficiently deacidify lysosomes. In contrast, an analogue without a morpholinyl group exhibits much lower ability to localize in lysosomes and is much less active in regulating the lysosomal pH | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Yu, Xi-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kun |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Wen-Hua |e verfasserin |4 aut | |
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