Heme metabolism as a therapeutic target against protozoan parasites
Neglected tropical diseases caused by protozoan parasites affect the life of millions of people worldwide, causing mortality, morbidity and high economic and social burden. The search for new drug targets and therapeutic strategies to fight these pathogens are necessary, since many current drugs have limited effects, cause severe side effects and their use has resulted in pathogen resistance. Heme (iron protoporphyrin IX) is a ubiquitous molecule important in many biological processes, including the homeostasis, growth and development of human pathogens such as trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp.) and Plasmodium spp. In this review, several chemotherapy approaches and strategies are discussed that target heme transport, catabolism, crystallization and hemeproteins.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Journal of drug targeting - 27(2019), 7 vom: 01. Aug., Seite 767-779 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lechuga, Guilherme Curty [VerfasserIn] |
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| Links: |
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| Themen: |
42VZT0U6YR |
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| Anmerkungen: |
Date Completed 27.07.2020 Date Revised 27.07.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/1061186X.2018.1536982 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM289675456 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Neglected tropical diseases caused by protozoan parasites affect the life of millions of people worldwide, causing mortality, morbidity and high economic and social burden. The search for new drug targets and therapeutic strategies to fight these pathogens are necessary, since many current drugs have limited effects, cause severe side effects and their use has resulted in pathogen resistance. Heme (iron protoporphyrin IX) is a ubiquitous molecule important in many biological processes, including the homeostasis, growth and development of human pathogens such as trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp.) and Plasmodium spp. In this review, several chemotherapy approaches and strategies are discussed that target heme transport, catabolism, crystallization and hemeproteins | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Heme | |
| 650 | 4 | |a drugs | |
| 650 | 4 | |a heme-oxygenase | |
| 650 | 4 | |a leishmaniasis | |
| 650 | 4 | |a malaria | |
| 650 | 4 | |a neglected diseases | |
| 650 | 4 | |a photodynamic therapy | |
| 650 | 4 | |a trypanosomiasis | |
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| 650 | 7 | |a Heme |2 NLM | |
| 650 | 7 | |a 42VZT0U6YR |2 NLM | |
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| 700 | 1 | |a Bourguignon, Saulo C |e verfasserin |4 aut | |
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