Integrative Molecular Characterization of Malignant Pleural Mesothelioma
©2018 American Association for Cancer Research..
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkpoint gene VISTA in epithelioid MPM, strikingly higher than in other solid cancers, with implications for the immune response to MPM and for its immunotherapy. Our findings highlight new avenues for further investigation of MPM biology and novel therapeutic options. SIGNIFICANCE: Through a comprehensive integrated genomic study of 74 MPMs, we provide a deeper understanding of histology-independent determinants of aggressive behavior, define a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expression of the immune-checkpoint gene VISTA in epithelioid MPM.See related commentary by Aggarwal and Albelda, p. 1508.This article is highlighted in the In This Issue feature, p. 1494.
| Errataetall: |
CommentIn: Cancer Discov. 2018 Dec;8(12):1508-1510. - PMID 30510013 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Cancer discovery - 8(2018), 12 vom: 21. Dez., Seite 1548-1565 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hmeljak, Julija [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 23.12.2019 Date Revised 05.04.2022 published: Print-Electronic CommentIn: Cancer Discov. 2018 Dec;8(12):1508-1510. - PMID 30510013 Citation Status MEDLINE |
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| doi: |
10.1158/2159-8290.CD-18-0804 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM289576962 |
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| 500 | |a CommentIn: Cancer Discov. 2018 Dec;8(12):1508-1510. - PMID 30510013 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a ©2018 American Association for Cancer Research. | ||
| 520 | |a Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1 alterations to date. We identified histology-independent molecular prognostic subsets, and defined a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity. We also report strong expression of the immune-checkpoint gene VISTA in epithelioid MPM, strikingly higher than in other solid cancers, with implications for the immune response to MPM and for its immunotherapy. Our findings highlight new avenues for further investigation of MPM biology and novel therapeutic options. SIGNIFICANCE: Through a comprehensive integrated genomic study of 74 MPMs, we provide a deeper understanding of histology-independent determinants of aggressive behavior, define a novel genomic subtype with TP53 and SETDB1 mutations and extensive loss of heterozygosity, and discovered strong expression of the immune-checkpoint gene VISTA in epithelioid MPM.See related commentary by Aggarwal and Albelda, p. 1508.This article is highlighted in the In This Issue feature, p. 1494 | ||
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