Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations
Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
Nature communications - 9(2018), 1 vom: 09. Okt., Seite 4169 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ho, Nhan T [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 02.01.2019 Date Revised 28.09.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41467-018-06473-x |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM289370477 |
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| 520 | |a Previous studies on the differences in gut microbiota between exclusively breastfed (EBF) and non-EBF infants have provided highly variable results. Here we perform a meta-analysis of seven microbiome studies (1825 stool samples from 684 infants) to compare the gut microbiota of non-EBF and EBF infants across populations. In the first 6 months of life, gut bacterial diversity, microbiota age, relative abundances of Bacteroidetes and Firmicutes, and predicted microbial pathways related to carbohydrate metabolism are consistently higher in non-EBF than in EBF infants, whereas relative abundances of pathways related to lipid metabolism, vitamin metabolism, and detoxification are lower. Variation in predicted microbial pathways associated with non-EBF infants is larger among infants born by Caesarian section than among those vaginally delivered. Longer duration of exclusive breastfeeding is associated with reduced diarrhea-related gut microbiota dysbiosis. Furthermore, differences in gut microbiota between EBF and non-EBF infants persist after 6 months of age. Our findings elucidate some mechanisms of short and long-term benefits of exclusive breastfeeding across different populations | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Li, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Lee-Sarwar, Kathleen A |e verfasserin |4 aut | |
| 700 | 1 | |a Tun, Hein M |e verfasserin |4 aut | |
| 700 | 1 | |a Brown, Bryan P |e verfasserin |4 aut | |
| 700 | 1 | |a Pannaraj, Pia S |e verfasserin |4 aut | |
| 700 | 1 | |a Bender, Jeffrey M |e verfasserin |4 aut | |
| 700 | 1 | |a Azad, Meghan B |e verfasserin |4 aut | |
| 700 | 1 | |a Thompson, Amanda L |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Scott T |e verfasserin |4 aut | |
| 700 | 1 | |a Azcarate-Peril, M Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Litonjua, Augusto A |e verfasserin |4 aut | |
| 700 | 1 | |a Kozyrskyj, Anita L |e verfasserin |4 aut | |
| 700 | 1 | |a Jaspan, Heather B |e verfasserin |4 aut | |
| 700 | 1 | |a Aldrovandi, Grace M |e verfasserin |4 aut | |
| 700 | 1 | |a Kuhn, Louise |e verfasserin |4 aut | |
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