Site-Specific Oxidative C-H Chalcogenation of (Hetero)Aryl-Fused Cyclic Amines Enabled by Nanocobalt Oxides
By employing reusable nanocobalt oxides as the catalysts, a site-specific oxidative C-H chalcogenation of (hetero)aryl-fused cyclic amines with various thiols and diselenides is presented for the first time. The reaction proceeds selectively at the sites of the (hetero)aryl rings para to the N atom, and enables access to a wide array of chalcogenyl N-heteroarenes. The merits of the transformation involve high step- and atom-efficiency, excellent substrate and functional compatibility, operational simplicity, and the use of a naturally abundant Co/O2 system. The present work has offered a fundamental basis for the selective synthesis of functional N-heteroarenes from readily available feedstocks.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Organic letters - 20(2018), 20 vom: 19. Okt., Seite 6554-6558 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tan, Zhenda [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 07.03.2019 Date Revised 07.03.2019 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.8b02889 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM289203384 |
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| 500 | |a Date Revised 07.03.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a By employing reusable nanocobalt oxides as the catalysts, a site-specific oxidative C-H chalcogenation of (hetero)aryl-fused cyclic amines with various thiols and diselenides is presented for the first time. The reaction proceeds selectively at the sites of the (hetero)aryl rings para to the N atom, and enables access to a wide array of chalcogenyl N-heteroarenes. The merits of the transformation involve high step- and atom-efficiency, excellent substrate and functional compatibility, operational simplicity, and the use of a naturally abundant Co/O2 system. The present work has offered a fundamental basis for the selective synthesis of functional N-heteroarenes from readily available feedstocks | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Liang, Yantang |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Huanfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Min |e verfasserin |4 aut | |
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