Live imaging of cell membrane-localized MT1-MMP activity on a microfluidic chip
We designed an enzyme-activatable probe for real time in situ tracking of MT1-MMP activity. The MT1-MMP responses of endothelial cells were investigated under the regulation of shear stress and biochemical factor on a microfluidic chip. This strategy can be beneficial to evaluate membrane protein responses to external stimuli and to engineer cells for basic and clinical research.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 54(2018), 81 vom: 09. Okt., Seite 11435-11438 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Nan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.11.2018 Date Revised 13.11.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.1039/c8cc07117a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM288872207 |
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| 520 | |a We designed an enzyme-activatable probe for real time in situ tracking of MT1-MMP activity. The MT1-MMP responses of endothelial cells were investigated under the regulation of shear stress and biochemical factor on a microfluidic chip. This strategy can be beneficial to evaluate membrane protein responses to external stimuli and to engineer cells for basic and clinical research | ||
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